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Chemical Chain-of-Thought Functions as a Hallucination-Prone Molecular Scratchpad

arXiv:2607.20935v1 Announce Type: cross Abstract: Chemical reasoning language models are expected to derive molecular answers through faithful chain-of-thought (CoT). However, across four reasoning model families and twelve chemistry tasks, hallucination is widespread and largely decoupled from answer correctness: correct answers often coexist with fabricated structural claims absent from the relevant molecules. Yet this does not make the reasoning trace computationally irrelevant. Attribution analyses suggest a shared scratchpad function expressed in model-specific forms: Chem-R and ether-0 rely on fragmented SMILES drafts, whereas ChemDFM-R emphasizes scaffold, positional, and naming cues. Notably, perturbing Chem-R’s SMILES sketches degrades generation, showing that structural drafts can be causally load-bearing even when verbal structural claims are largely inert. Together, these results show that chemical CoT is neither a faithful explanation nor merely a post-hoc rationalization, but a hallucination-prone molecular scratchpad. This finding cautions against treating CoT as direct evidence of faithful reasoning and motivates process-level supervision beyond answer-only evaluation.

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How to Build an End-to-End OCR Pipeline with Baidu’s Unlimited-OCR for High-Resolution Images and Multi-Page PDF Parsing

In this tutorial, we build a complete workflow for running Baidu’s Unlimited-OCR model on document images and multi-page PDFs. We configure the GPU environment, install the required dependencies, load the 3B-parameter vision-language model with automatic selection of bfloat16 or float16, and generate structured sample documents for testing. We then evaluate both the tiled Gundam inference mode and the faster Base mode for single-page OCR before extending the pipeline to multi-page PDF parsing with PyMuPDF and infer_multi(). Throughout the workflow, we preserve long-context generation settings, repetition controls, and structured output handling to process dense layouts, tables, paragraphs, and cross-page content in a reproducible end-to-end pipeline. Copy CodeCopiedUse a different Browser import subprocess, sys def pip_install(*pkgs): subprocess.check_call([sys.executable, “-m”, “pip”, “install”, “-q”, *pkgs]) print(“>> Installing dependencies (1-2 min)…”) pip_install( “transformers==4.57.1”, “Pillow”, “matplotlib”, “einops”, “addict”, “easydict”, “pymupdf”, “psutil”, “accelerate”, ) print(“>> Done.”) import os import torch from transformers import AutoModel, AutoTokenizer assert torch.cuda.is_available(), ( “No GPU detected! In Colab: Runtime -> Change runtime type -> GPU.” ) gpu_name = torch.cuda.get_device_name(0) print(f”>> GPU: {gpu_name}”) use_bf16 = torch.cuda.is_bf16_supported() DTYPE = torch.bfloat16 if use_bf16 else torch.float16 print(f”>> Using dtype: {DTYPE}”) MODEL_NAME = “baidu/Unlimited-OCR” print(“>> Downloading model (~6 GB for 3B params in BF16). First run takes a while…”) tokenizer = AutoTokenizer.from_pretrained(MODEL_NAME, trust_remote_code=True) model = AutoModel.from_pretrained( MODEL_NAME, trust_remote_code=True, use_safetensors=True, torch_dtype=DTYPE, ) model = model.eval().cuda() print(“>> Model loaded and moved to GPU.”) We install the required libraries and prepare the Google Colab environment for Unlimited-OCR inference. We verify that a CUDA-enabled GPU is available and automatically choose bfloat16 or float16 based on hardware support. We then load the tokenizer and the 3B-parameter model from Hugging Face, switch them to evaluation mode, and move them to the GPU. Copy CodeCopiedUse a different Browser from PIL import Image, ImageDraw, ImageFont import textwrap os.makedirs(“inputs”, exist_ok=True) os.makedirs(“outputs/single_gundam”, exist_ok=True) os.makedirs(“outputs/single_base”, exist_ok=True) os.makedirs(“outputs/multi_page”, exist_ok=True) def load_font(size): for path in [ “/usr/share/fonts/truetype/dejavu/DejaVuSans-Bold.ttf”, “/usr/share/fonts/truetype/dejavu/DejaVuSans.ttf”, ]: if os.path.exists(path): return ImageFont.truetype(path, size) return ImageFont.load_default() def make_sample_page(path, page_no): W, H = 1240, 1754 img = Image.new(“RGB”, (W, H), “white”) d = ImageDraw.Draw(img) title_f, head_f, body_f = load_font(48), load_font(34), load_font(26) d.text((80, 70), f”Quarterly Operations Report — Page {page_no}”, fill=”black”, font=title_f) d.line([(80, 145), (W – 80, 145)], fill=”black”, width=3) body = ( “This document demonstrates Unlimited-OCR’s one-shot long-horizon ” “parsing. The model reads an entire page — headings, paragraphs, ” “and tables — and emits structured text in a single decoding pass. ” “Unlike classic OCR pipelines, no separate layout-analysis stage ” “is required.” ) y = 190 for line in textwrap.wrap(body, width=72): d.text((80, y), line, fill=”black”, font=body_f) y += 40 y += 30 d.text((80, y), f”Table {page_no}: Regional Revenue (USD, millions)”, fill=”black”, font=head_f) y += 60 rows = [ [“Region”, “Q1”, “Q2”, “Q3”], [“North”, “12.4”, “13.1”, “15.0”], [“South”, “9.8”, “10.2”, “11.7”], [“East”, “14.3”, “13.9”, “16.2”], [“West”, “11.1”, “12.5”, “12.9”], ] col_w, row_h, x0 = 260, 56, 80 for r, row in enumerate(rows): for c, cell in enumerate(row): x = x0 + c * col_w d.rectangle([x, y, x + col_w, y + row_h], outline=”black”, width=2) d.text((x + 14, y + 12), cell, fill=”black”, font=body_f) y += row_h y += 50 footer = ( f”Note {page_no}: Figures are illustrative. Multi-page mode stitches ” “context across pages, so cross-page references remain coherent.” ) for line in textwrap.wrap(footer, width=72): d.text((80, y), line, fill=”black”, font=body_f) y += 40 img.save(path) return path IMAGE_PATH = make_sample_page(“inputs/sample_page_1.png”, 1) PAGE_2 = make_sample_page(“inputs/sample_page_2.png”, 2) PAGE_3 = make_sample_page(“inputs/sample_page_3.png”, 3) print(f”>> Sample pages written: {IMAGE_PATH}, {PAGE_2}, {PAGE_3}”) import matplotlib.pyplot as plt plt.figure(figsize=(6, 8)) plt.imshow(Image.open(IMAGE_PATH)) plt.axis(“off”) plt.title(“Input document (page 1)”) plt.show() We create the required input and output directories and generate three realistic sample document pages with PIL. We add headings, paragraphs, tables, and footnotes to test the model on structured, layout-rich content. We also preview the first generated page with Matplotlib before sending it to the OCR pipeline. Copy CodeCopiedUse a different Browser print(“n” + “=” * 76) print(“STEP 4: Single image — GUNDAM mode (tiled, high detail)”) print(“=” * 76) model.infer( tokenizer, prompt=”<image>document parsing.”, image_file=IMAGE_PATH, output_path=”outputs/single_gundam”, base_size=1024, image_size=640, crop_mode=True, max_length=32768, no_repeat_ngram_size=35, ngram_window=128, save_results=True, ) We run single-image OCR using Gundam mode, which combines a global document view with tiled image crops. We enable crop_mode and use a smaller tile size to preserve fine text and improve recognition on dense document layouts. We also configure long-output generation and repetition controls to ensure the model produces stable, structured results. Copy CodeCopiedUse a different Browser print(“n” + “=” * 76) print(“STEP 5: Single image — BASE mode (single view, faster)”) print(“=” * 76) model.infer( tokenizer, prompt=”<image>document parsing.”, image_file=IMAGE_PATH, output_path=”outputs/single_base”, base_size=1024, image_size=1024, crop_mode=False, max_length=32768, no_repeat_ngram_size=35, ngram_window=128, save_results=True, ) We process the same document using Base mode with a single 1024-pixel image view. We turn off image cropping to reduce inference complexity and improve processing speed for clean, clearly printed pages. We retain the same output length and repetition-control settings to directly compare Base mode with Gundam mode. Copy CodeCopiedUse a different Browser print(“n” + “=” * 76) print(“STEP 6: Multi-page / PDF parsing”) print(“=” * 76) import tempfile import fitz def pdf_to_images(pdf_path, dpi=300): “””Rasterize every PDF page to a PNG; return the list of image paths.””” doc = fitz.open(pdf_path) tmp_dir = tempfile.mkdtemp(prefix=”pdf_ocr_”) mat = fitz.Matrix(dpi / 72, dpi / 72) paths = [] for i, page in enumerate(doc): out = os.path.join(tmp_dir, f”page_{i + 1:04d}.png”) page.get_pixmap(matrix=mat).save(out) paths.append(out) doc.close() return paths SAMPLE_PDF = “inputs/sample_doc.pdf” pdf = fitz.open() for p in [IMAGE_PATH, PAGE_2, PAGE_3]: img_doc = fitz.open(p) rect = img_doc[0].rect pdf_bytes = img_doc.convert_to_pdf() img_pdf = fitz.open(“pdf”, pdf_bytes) page = pdf.new_page(width=rect.width, height=rect.height) page.show_pdf_page(rect, img_pdf, 0) pdf.save(SAMPLE_PDF) pdf.close() print(f”>> Built sample PDF: {SAMPLE_PDF}”) page_images = pdf_to_images(SAMPLE_PDF, dpi=300) print(f”>> Rasterized {len(page_images)} pages”) model.infer_multi( tokenizer, prompt=”<image>Multi page parsing.”, image_files=page_images, output_path=”outputs/multi_page”, image_size=1024, max_length=32768, no_repeat_ngram_size=35, ngram_window=1024, save_results=True, ) We create a three-page PDF from the generated document images and rasterize each page of the PDF into a high-resolution PNG using PyMuPDF. We pass the resulting page-image sequence to infer_multi() so that the model can parse the complete document in a single long-horizon inference operation. We also widen the n-gram repetition window to maintain stable decoding across multiple pages. Copy CodeCopiedUse a different Browser print(“n”

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AI, Committee, Notizie, Uncategorized

The Download: an organ transplant breakthrough, and homegrown Chinese chips

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Supercooled kidneys have been transplanted into pigs in a “landmark achievement”  When it comes to organ donation, time is everything. As soon as an organ has been removed from a donor’s body, it starts to deteriorate. Surgeons have only a matter of hours to get it into a recipient. In most cases, organs will be kept on ice during that time, at around 4 °C (39 °F). They cannot be frozen—in previous attempts, ice has formed, causing all kinds of damage. But now, scientists have come up with a device that allows organs to be cooled to -4 °C (25 °F) without forming any ice. They’ve tested it with pig organs and shown that kidneys, at least, can be preserved in the device for days then successfully transplanted.  Read our story about their breakthrough, and why it raises hopes for longer-term storage of donated human organs. —Jessica Hamzelou If you want to read more about this story and its implications for organ preservation and transplantation, sign up to receive The Checkup, our weekly biotech newsletter, later today. The must-reads I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology. 1 Inside China’s epic push to replace US chips The gap between their chips’ capabilities remains large—for now. (WSJ $)+ How China is using open source AI as a new form of soft power around the globe. (NYT $)+ A new bill in the US takes aim at Chinese AI companies’ training practices. (NBC)+ US lawmakers are also mulling banning the military from using Chinese humanoid robots. (SCMP) 2 Space data centers don’t exist yet, but people already oppose themEnvironmental experts warn it’ll further pollute the stratosphere. (Guardian)+ Four things we’d need to put data centers in space. (MIT Technology Review)+ What it’s like inside the data centers powering AI down here on Earth. (Axios)+ The left and right are finding common cause with data center protests in the US. (The Verge) 3 US lawmakers are pushing for an AI ‘kill switch’After OpenAI’s models went rogue and hacked Hugging Face. (BBC) 4 Peptides seem on the cusp of going mainstream in the USA lack of scientific evidence didn’t stop the FDA just voting to let some pharmacies to legally dispense them. (Wired $)+ How does Make America Healthy Again hold up to scientific scrutiny? (Nature)+ US measles cases are reaching levels not seen for three decades. (Wired $)+ Peptides are everywhere. Here’s what you need to know. (MIT Technology Review) 5 The EU just fined Google almost $1 billionFor competition breaches over apps and search. (FT $)+ It came just a day before Trump renewed tariffs on 60 trading partners, including the EU. (BBC) 6 Electric vehicles are selling well in EuropeAnd the share made by Chinese firms has doubled in the last year. (The Next Web)+ Hybrids are hot property in the US this summer. (Wired $) 7 There’s a worsening shortage of computer science professorsYou can blame AI companies—they keep snapping them up, to our general detriment. (The Atlantic $) 8 A judge caught a stenographer allowing AI errors into their transcript It’s apparently the first time this has happened, but it certainly won’t be the last. (404 Media)+ Even judges themselves are falling for AI. (MIT Technology Review) 9 Here’s what new tech millionaires will do with their IPO wealth What a nice problem to have to grapple with! (Quartz $) 10 Dating apps’ latest wheeze? In-person events Well well well, it seems we’ve come full circle. (Bloomberg $) Quote of the day “Call us optimists, call us dreamers. Just as we’ve always done, we’re betting on people.”  —The voiceover from a new advert from Meta, which exhorts us to be more optimistic about AI. One More Thing BELL HUTLEY AI is changing how we study bird migration In a warming world increasingly full of human infrastructure that can be deadly to them, like glass skyscrapers and power lines, migratory birds are facing many existential threats.  Scientists rely on a combination of methods to track the timing and location of their migrations, though each has shortcomings. But now, machine-learning tools are unlocking a treasure trove of acoustic data for ecologists.  Read our story about the technology that’s making it easier to detect and identify birds and their movements. —Christian Elliott We can still have nice things A place for comfort, fun, and distraction to brighten up your day. (Got any ideas? Drop me a line.) + It’s never too late to live your dreams. Here’s how these late bloomers did it.+ Limbs feeling a bit tight? Try these stretches!+ These English football fans went to the 1986 World Cup—and loved it so much they never came home.+ How the invention of the humble paint tube revolutionized the world of art.

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The quest to keep organs alive outside the body

This week, I covered a fascinating effort to preserve organs outside the body. There’s a huge shortage of donor organs, and one of the main reasons is time—they survive only a matter of hours outside the body, even when they’re kept on ice. Doctors dream of organ banks—stores of human organs that can be preserved for days, weeks, months, or even longer. That would allow them to run tests on organs, find the best matches for them, and transport the organs to those recipients. In new research, one team has been able to supercool the kidneys of pigs—animals whose organs are of a similar size to human ones—and preserve them for days. The kidneys survived being stored at −4 °C (25 °F) and eventually reimplanted back into pigs. And that’s just the latest development in a field that is positively buzzing. It has proved super difficult to freeze organs. Once ice forms in them, they’re done. The ice crystals create all kinds of damage and render the organs unusable. That hasn’t stopped many researchers from trying. Some have focused on cryopreservation—rapid extreme cooling that essentially leaves cells in a glasslike state. This process is now routine for eggs, sperm, and embryos, which are cooled to −196 °C in less than two seconds and can be used even after decades in storage. No one has managed to cryopreserve and thaw human organs for transplantation. But plenty of human bodies and brains have been stored at ultra-low temperatures in the hope that they might one day be rewarmed and brought back to life. (You can read more about why some people opt for cryonics here.) In March, I wrote about Stephen L. Coles, a gerontologist who had opted to cryopreserve his own brain. After the scientist died in 2014, his body was taken to Alcor, a cryonics facility in Arizona. A team at the facility removed Coles’s head, perfused his brain with cryoprotective chemicals (which work like antifreeze), removed the brain from the skull, and cooled it to −146 °C. When Coles’s friend Greg Fahy, a cryobiologist, studied pieces of his brain years later, he found that the brain cells, which had shrunk, “bounced back” once they were rewarmed. But that doesn’t mean the cells are alive, or that it might one day be possible to reanimate the brain. As Matthew Powell Palm of Texas A&M told me at the time: “There are so many ways those neurons could be toast.” Powell Palm is working on other ways to preserve organs. It was he, along with his colleagues, who managed to store supercooled pig kidneys and successfully transplant them, in a study described as “a landmark achievement.” Those organs did better than kidneys stored on ice, he says. His approach didn’t require cryoprotectants. But other teams are exploring potential chemical cocktails that might allow them to store organs at lower temperatures, potentially for longer periods of time. (More on this in The Checkup soon!) Another way to prolong the lifespan of an organ is to use a machine that perfuses it with nutrients, mimicking what happens inside the body. Machine perfusion devices have become more commonly used over the last decade or so and are typically used to maintain livers and kidneys for up to about 24 hours. Researchers are now adapting this protocol for a growing list of organs, even eyeballs—a recent feat that might enable whole-eye transplants. In March, I went to visit scientists in Valencia who had developed a perfusion system for uteruses. They had used their device—which they nicknamed “Mother”—to keep a human uterus alive for a day. It’s an exciting time for organ preservation. Keep an eye out for more coverage from MIT Technology Review in the coming weeks. This article first appeared in The Checkup, MIT Technology Review’s weekly biotech newsletter. To receive it in your inbox every Thursday, and read articles like this first, sign up here.

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The Download: energy transmission and US threats against Chinese AI

This is today’s edition of The Download, our weekday newsletter that provides a daily dose of what’s going on in the world of technology. The power line that could reshape New York’s grid is hitting snags  During a heat wave on July 3, New York State’s grid imported enough electricity from Canada to meet about 9% of its total demand that day. Some of that power shuttled in on a 339-mile power line stretching from Quebec to Queens. It opened in May and is officially the longest underground transmission line in North America. It could provide up to 20% of New York City’s electricity demand, largely with abundant hydropower from Quebec. One wrinkle: The line has been down for most of this month, and some experts are concerned about how drought will affect the power supply feeding it.  Still, the line could help shape the future of our grid, if it can overcome these sorts of snags. Read our story to understand how. —Casey Crownhart This story is from The Spark, our weekly climate tech newsletter. Sign up to receive it in your inbox every Wednesday. The must-reads I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology. 1 The US Treasury is threatening to sanction Chinese AI companiesTreasury secretary Scott Bessent has accused Moonshot of improperly distilling Anthropic’s Fable model. (TechCrunch)+ Nvidia’s Jensen Huang is arguing that America has nothing to fear from Chinese AI. (Axios)+ Like it or not, Chinese models are now part of the global AI infrastructure. (Rest of World)+ China’s AI models have Trump’s AI world at war with itself. (MIT Technology Review) 2 Why the OpenAI hack is the scariest AI mishap yetAI’s capabilities seem to be starting to outpace our current ability to control them. (The Economist $)+ Hugging Face had to turn to a Chinese AI model to rescue it from the hack. (BI) 3 Visually impaired Europeans can now get an implant that restores sightAnd Americans may not have to wait long to receive it, too. (STAT)+ This retina implant lets people with vision loss do a crossword puzzle. (MIT Technology Review) 4 A bellwether lawsuit suing Meta for social media addiction has been droppedThere are, however, many more waiting in the wings. (NYT $) 5 Here’s how ICE gets its hands on Americans’ dataAs soon as you open a credit card or phone account, its agents can see where you live. (404 Media)+ States are warring with the Trump administration over the right to see ICE agents’ faces. (Wired $) 6 We urgently need to grapple with AI’s environmental impactAs the world warms, is the price we’re paying worth it? (The Verge)+ We did the math on AI’s energy footprint. (MIT Technology Review) 7 Privacy issues with smart glasses need an industrywide fixThat’s according to Samsung, which is unveiling glasses it developed with Google this fall. (Bloomberg $) 8 The US Army is begging soldiers to limit their AI useThe token crisis comes for us all eventually, it seems. (Ars Technica) 9 Why does lettuce keep making Americans sick? It’s pretty simple: a lot of people eat it, and it doesn’t get cooked. (Wired $) 10 Pokemon Go is the perfect game to play this summerIt’s fun, collaborative, and it gets you outdoors. (Guardian) Quote of the day “It went off and did this hack all by itself, as far as we can tell. This is the highest level of autonomy that we’ve seen in the use of a large language model for cyber operations.” —Colin Shea-Blymyer, a cybersecurity research fellow at Georgetown University, tells NPR why the OpenAI hack on Hugging Face is so alarming.  One More Thing KAGAN MACLEOD Welcome to the dark side of crypto’s permissionless dream  Jean-Paul Thorbjornsen is a founder of THORChain, a blockchain through which users can swap one cryptocurrency for another and earn fees from making those swaps.   But is he responsible for what it’s used for? It’s a question that matters because in January last year, its users lost more than $200 million in cryptocurrency after THORChain transactions and accounts were frozen by an admin override, which users believed was not supposed to be possible given the decentralized structure. It’s also been used by North Korean hackers to move $1.2 billion of stolen ethereum.  Thorbjornsen explains this all away as a function of THORChain’s decentralized and permissionless nature. Read our story exploring whether we should believe him or not.  —Jessica Klein We can still have nice things A place for comfort, fun, and distraction to brighten up your day. (Got any ideas? Drop me a line.) + A musician developed an ingenious way to strum a guitar with an electric fan.+ Ukraine’s tunnel of love is a leafy green corridor of romance that’s straight out of a fairy tale.+ The driver of a giant banana has been pulled over 100s of times, but still won’t ditch his treasured ride.+ Ever wonder which albums and songs truly stand the test of time? The Greatest Music tries to answer that via an algorithm that analyses hundreds of “best of” lists.

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You Didn’t Get the AI Model You Paid For

The line in the response object You call the API. You pass model: “claude-fable-5”. You get back a completion, a token count, and a field that reads “model”: “claude-opus-4-8”. Nothing errored. Nothing retried. The request was classified before generation began, matched a sensitive category, and was handed to a different set of weights entirely. Anthropic documented this when it brought Fable 5 back on July 1: blocked requests are sent to Opus 4.8 instead, and the user is notified. The switch happens at the API layer, and the response object names the model that actually ran. That is the well-behaved version. It is also, as far as I can tell, the only version in wide deployment that tells you the truth in-band. Two weeks later, Cursor shipped Router: a classifier trained on 600,000-plus live requests that reads each query’s context, complexity, and domain and dispatches it to whichever model it judges best with three early-access accounts reporting 30–50% savings against routing everything to Opus 4.8. Cursor published its routing rules but did not name a specific model per task type. And underneath both, at the aggregation layer, OpenRouter warns that some providers serve quantized weights at lower prices, that output can differ from what full-precision weights would have produced, and that your logs will not tell you this happened. Three products. Three different answers to the question what is a model. Zero cases telling us which one the law will accept. Three ways a name can stop meaning a thing Model identity is fracturing along three independent axes, and they are not usually distinguished: Substitution – A different architecture, different weights, different capability profile – dispatched by a classifier. Fable 5 → Opus 4.8. Cursor Auto → whatever the router picks this turn. Degradation – The same model, served at reduced precision. OpenRouter exposes a quantizations parameter precisely because quantized endpoints may perform worse on certain prompts, and by default requests are load-balanced across providers ordered by price. Same name in your request. Different arithmetic on the other end. Drift – The same name pointing at silently updated weights. Every -latest alias in production is an unversioned dependency you would never tolerate in a package manifest. The engineering community treats all three as reliability problems. They are also identity problems, and identity is what contracts, warranties, disclosures, and evidence rules are built on. So what did you actually buy? Start with the oldest question in commercial law: was the description a term of the deal? If an API call were a sale of goods, this would be near-trivial. UCC §2-313(1)(b) makes any description of the goods that forms part of the basis of the bargain into an express warranty that the goods will conform to it. India’s Sale of Goods Act, 1930, §15 does the same work through the doctrine of sale by description. But an inference API almost certainly isn’t goods. Courts have generally treated hosted software as a service, which pushes you out of warranty statutes and into common-law contract — where the answer depends entirely on what the documentation said and how specifically the buyer bargained. That is precisely where the ambiguity lives. Enterprise agreements price per-model. Model cards are model-specific. Compliance artifacts name model versions. And then the routing layer treats the name as a hint. The cleanest way to see the stakes: if your code pins a model ID rather than expressing a capability requirement, behaviour can shift materially without any error ever firing. A contract drafted the same way has the same defect. If you bargained for a name, substitution is breach. If you bargained for a capability, substitution is fine — and now you need a definition of “frontier quality” that survives cross-examination. Nobody has written that definition. Cursor’s is instructive: Router was evaluated in an online A/B test optimising for user satisfaction as the reward signal. That is a sound engineering choice and a strange contractual one. Satisfaction is not conformity. A user who never noticed the swap is evidence of a good router, not of a delivered specification. The disclosure gradient Under FTC deception doctrine, a representation is actionable when it is material and likely to mislead a consumer acting reasonably; objective performance claims additionally require a reasonable basis before dissemination. Both halves bite here. On the routing side, the three products sit at very different points. Anthropic notifies and returns the served model in the response. Cursor publishes rules but not per-task model assignment. OpenRouter’s quantization variance is disclosed in documentation and controllable by parameter but it is opt-out, and the default path is the cheap one. Disclosure buried in a docs page, defaulted against the user, is exactly the fact pattern regulators have been calling a dark pattern in every other consumer vertical. On the substantiation side, the exposure is the claim, not the routing. Commentators have already flagged that a “60% cheaper, no quality loss” claim arrives without published methodology, and Anthropic’s own disclosure is a model of what candour costs: it stated plainly that the retrained classifier flags benign requests more often during routine coding and debugging. That sentence is a liability shield. The vendors who don’t write it are the ones to watch. There is a competition-law tail here too. Working papers on vertical foreclosure in inference markets are already proposing a conduct framework built on routing transparency, quality-of-service parity, and FRAND-style non-discrimination. A router that is also a first-party model vendor is a self-preferencing engine wearing a cost-optimisation costume. The part nobody is looking at: authentication This is where I think the real fight lands, and it has nothing to do with billing. Federal Rule of Evidence 901(b)(9) authenticates output by describing the process or system that produced it and showing that the process produces an accurate result. FRE 902(13) and 902(14) go further, letting records generated by an electronic system, or data verified by hash, self-authenticate on certification. India’s Bharatiya Sakshya Adhiniyam, 2023, §63 does the analogous work, conditioning admissibility of an electronic

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Supercooled kidneys have been transplanted into pigs in a “landmark achievement”

When it comes to organ donation, time is everything. As soon as an organ has been carefully removed from a donor’s body, it starts to deteriorate. Surgeons have a matter of hours to get it into a recipient. Leave it too long and the organ will become unusable. In most cases, organs will be kept on ice during that time, at around 4 °C (39 °F). They cannot be frozen—in previous attempts, ice has formed, causing all kinds of damage. Matthew Powell Palm at Texas A&M University and his colleagues have an alternative solution—a device that allows organs to be cooled to -4 °C (25 °F) without forming any ice. Now, in new research with pig organs, his team has shown that kidneys, at least, can be supercooled and preserved in the device for days. Once rewarmed, the organs have been successfully transplanted into animals, and they seem to do better than organs kept on ice. The work represents “a landmark achievement,” says Kevin Myer, president and CEO of LifeGift, an organ procurement organization based in Texas, who was not involved in the research. Cooling organs Powell Palm hopes this approach could ultimately help ease the organ shortage crisis. Today, there are more than 104,000 people waiting for a kidney transplant in the US alone. It is estimated that 17 people die every day in the US while waiting for a transplant. That’s partly due to a lack of donated kidneys, but it’s also because many of those that are available never make it to a recipient. In some years, around one in three donated kidneys end up being discarded, often because they end up too degraded to use by the time they reach a recipient. Kidneys can be stored on ice for around 24 hours or placed in devices that aim to mimic the conditions of the body, also for up to around 24 hours. That’s not always long enough to find a suitable recipient and transport the organ, says Myer. Scientists around the world have been working on ways to store organs for longer by cooling them to even chillier temperatures. Cooling an organ slows its metabolism—the colder you go, the greater the effect, and the longer you can store it. We’ve long been able to successfully cryopreserve eggs, sperm, and embryos, but it’s much harder to freeze large organs. Teams have been exploring various temperatures and cryoprotectants (chemicals that essentially work like antifreeze), but so far no one has been able to freeze human organs for transplantation.   As a thermodynamicist, Powell Palm explored another approach. By keeping an organ submerged at a constant pressure, it should be possible to prevent the formation of ice at temperatures a little below 0 °C, without the need for cryoprotectants (which might have side effects and would need to be approved before being used in human transplants).  To test this theory, Powell Palm and his colleagues have created a device that does just that. The device itself is essentially a hermetically sealed chamber with a transparent lid. At its base is a device that monitors the organ’s temperature and checks for the formation of ice. Organs are submerged in a solution that is already commonly used to preserve them for transplant. “I always describe this as low-tech high science,” says Powell Palm. “A lot of work has gone into understanding the … kinetics at play in this system, but ultimately … it’s quite simple.” Supercooled kidneys To test their device, Powell Palm and his colleagues first removed single kidneys from pigs. The organs were flushed with the same commonly used solution to remove the blood, just as transplant organs are. The team then kept some kidneys on ice for either two hours or 24 hours, to mimic standard conditions used in human transplantation. They also put some of the removed kidneys in their device for 24, 48, or 72 hours. The stored kidneys were then each transplanted back into the original donor pigs. Each pig’s second kidney was removed in the same procedure, leaving each animal with only the kidney that had been stored, and reimplanted. Once the 24-hour supercooled kidneys were transplanted, they immediately began producing urine—a key indication that they were working. The team members also measured other markers of kidney function and found that the organs appeared to be working normally within about 10 days of being transplanted. A kidney that was supercooled for 72 hours recovers once it is transplanted back into a pig.COURTESY RONALD SELLERS, POWELL-PALM LAB, TEXAS A&M UNIVERSITY That’s slower than kidneys stored on ice for two hours but much quicker than kidneys kept on ice for 24 hours, says Powell Palm. The organs that were kept supercooled for 48 and 72 hours performed similarly, he says. “Even at three days—triple the clinical standard—we’re getting recovery that is faster than … [what has been] the gold standard for the last three decades,” he says. “So we’re really, really pumped about this.” “It is impressive,” says Heidi Yeh, a transplant surgeon at Mass General Brigham for Children, who also researches organ preservation technologies. “Often kidneys that have been stored for 48 hours [in other studies] take a week or two before they start working again.” Organs that grow The supercooled organs seem to work well in the long term, too. Over a 30-day period, the pigs grew by around 30%—and the kidneys grew with them, almost doubling in size to compensate for both the pigs’ growth and the lack of a second kidney. The team monitored one of the pigs for 200 days before removing and analyzing its kidney. Even at that point the organ looked healthy, says Powell Palm. He and his colleagues presented the findings at the American Transplant Congress in Boston last month. Earlier this year, researchers in Canada showed they could also cool pig kidneys to below-zero temperatures and transplant them into pigs. The team’s protocol included the use of a cryoprotectant, and organs were stored for up to 48

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AI, Committee, Notizie, Uncategorized

Andrew Ng Just Released OpenWorker: An Open-Source, Local-First Desktop AI Coworker That Returns Finished Deliverables Instead of Chat

Andrew Ng has announced OpenWorker, an open-source desktop agent that produces finished work rather than conversation. OpenWorker asks the user for an outcome, not a prompt: a polished document, a Slack reply containing the actual numbers, an updated calendar, a triaged inbox. It then breaks that outcome into steps, works across local files and connected apps, and checks in before anything consequential. The architecture is four layers, and all of them run on your machine The repository contains 119 Python files (~32,400 lines) under coworker/, 149 TypeScript/TSX files under surfaces/gui/, and 78 backend test modules. The stack breaks down as follows: Desktop shell — a Tauri 2 native window wrapping a React 18 UI. The bundle identifier is com.openworker.desktop, and the shell supervises the Python server itself. Local agent server — Python 3.10+ on FastAPI and uvicorn, binding to 127.0.0.1:8765 by default. The example config caps a turn at 12 modeltool iterations. Capability and connector layer — vetted local tools (files, git, ripgrep-backed search, shell, todo) plus hosted integrations plus MCP. Model router — one interface over native, OpenAI-compatible, reseller and local providers. The engine is built on aisuite, Andrew Ng’s provider-agnostic LLM library. Bring your own model, from a deliberately small curated list There is no OpenWorker inference service. The user pastes an API key, or points the app at a local runtime. The curated model matrix contains exactly 30 entries. Native providers cover OpenAI (GPT-5.6 Sol/Terra/Luna and GPT-5.5), Anthropic (Claude Fable 5, Opus 4.8, Sonnet 4.6, Haiku 4.5) and Google (Gemini 3.1 Pro, 3.6 Flash, 2.5 Pro, 2.5 Flash). OpenAI-compatible vendors add GLM-5.2, DeepSeek V4, Kimi K2.6, MiniMax M2.5, Qwen3 Max, Grok 4.3 and Mistral Large. Open-weight models arrive through Together AI and Fireworks, and fully local models through Ollama, which requires no key at all. The permission engine is the actual engineering story Most desktop agent projects treat approvals as a UI afterthought. OpenWorker treats them as a typed layer. Every tool call is classified into one of four risk classes: read (no side effects), write_local (mutates the workspace, path-scoped), exec (runs commands), and external (side effects off the machine). Five permission modes then decide what happens: discuss and plan are read-only, interactive is the default and asks before writes, commands and external actions, auto allows everything while remaining path-scoped, and custom auto-approves a user-listed set of tools. Two design decisions stand out. First, unattended mode does not raise the autonomy ceiling — it only changes where the human is reached. Prompts that would appear inline are routed to an Inbox, and the session suspends until answered. Second, task-scoped standing rules are restricted to external risk only. Shell commands ask forever, by design. The built-in ops persona also instructs the model to treat content from tools, logs, the web, files and incoming messages as untrusted data rather than instructions. That is an explicit prompt-injection posture, written into the shipped persona. Privacy: local-first Model calls go directly from the machine to the configured provider. Conversations, connector tokens and model keys stay local, and the secret store is designed so that secrets never enter the model’s context, prompts or traces. The only cloud component is an optional broker that handles OAuth handshakes for one-click connectors, using Auth0 Authorization Code with PKCE. Connector tokens are handed straight to the machine and are never stored in the cloud. The app is fully functional signed out, using manually pasted credentials. Key Takeaways OpenWorker is Andrew Ng’s MIT-licensed desktop AI coworker that returns finished deliverables, not chat replies. The stack is a Tauri 2 + React shell over a local Python FastAPI agent server built on aisuite. Model access is bring-your-own-key across 30 curated tool-calling models, plus fully local Ollama. A typed risk engine (read/write_local/exec/external) gates every action across five permission modes. Check out the GitHub Repo, the project site, and the announcement. All credit for this research goes to the researchers and developers of this project. The post Andrew Ng Just Released OpenWorker: An Open-Source, Local-First Desktop AI Coworker That Returns Finished Deliverables Instead of Chat appeared first on MarkTechPost.

Andrew Ng Just Released OpenWorker: An Open-Source, Local-First Desktop AI Coworker That Returns Finished Deliverables Instead of Chat Leggi l'articolo »

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