{"id":91437,"date":"2026-05-19T16:46:30","date_gmt":"2026-05-19T16:46:30","guid":{"rendered":"https:\/\/youzum.net\/colossal-biosciences-is-growing-chickens-in-a-3d-printed-artificial-eggshell\/"},"modified":"2026-05-19T16:46:30","modified_gmt":"2026-05-19T16:46:30","slug":"colossal-biosciences-is-growing-chickens-in-a-3d-printed-artificial-eggshell","status":"publish","type":"post","link":"https:\/\/youzum.net\/zh\/colossal-biosciences-is-growing-chickens-in-a-3d-printed-artificial-eggshell\/","title":{"rendered":"Colossal Biosciences is growing chickens in a 3D-printed artificial eggshell"},"content":{"rendered":"<div data-chronoton-summary=\"&lt;ul&gt;&lt;br&gt;&lt;li&gt;&lt;strong&gt;Artificial eggshell, not artificial egg:&lt;\/strong&gt; Colossal Biosciences has grown baby chicks inside 3D-printed plastic containers coated with a silicone-based membrane that mimics an eggshell's oxygen exchange \u2014 a meaningful step, but scientists say the company is overselling it.&lt;\/li&gt;&lt;br&gt;&lt;li&gt;&lt;strong&gt;The moa is one target:&lt;\/strong&gt; Colossal's goal is resurrecting the giant moa, a 12-foot flightless bird hunted to extinction \u2014 which would require genetically rewriting thousands of DNA letters and scaling up the artificial eggs to the size of a salad spinner.&lt;\/li&gt;&lt;br&gt;&lt;li&gt;&lt;strong&gt;Scientists are skeptical:&lt;\/strong&gt; Researchers have been growing birds in artificial containers since 1998 and say Colossal's claims of a first-ever breakthrough are overblown \u2014 a familiar pattern for a company that last year also faced widespread rejection of its &quot;dire wolf&quot; resurrection claim.&lt;\/li&gt;&lt;br&gt;&lt;\/ul&gt;\" data-chronoton-post-id=\"1137471\" data-chronoton-expand-collapse=\"1\" data-chronoton-analytics-enabled=\"1\"><\/div>\n<p>The baby chicks were shifting and starting to pip\u2014or trying to hatch. But not from an egg.\u00a0<\/p>\n<p>Instead, these chickens were growing inside transparent 3D-printed plastic cups at the Dallas headquarters of Colossal Biosciences.<\/p>\n<p>The biotech company today claimed it has developed a \u201cfully artificial egg\u201d as part of its effort to resurrect extinct avian species, including birds like the dodo and the giant moa.<\/p>\n<p>But \u201cartificial eggshell\u201d would probably be a better description for the invention. It\u2019s an oval-shaped printed lattice, coated inside with a special silicone-based membrane that lets in oxygen, just as a real eggshell does.\u00a0<\/p>\n<p>To generate birds, Colossal took recently laid chicken eggs and carefully poured their contents into the artificial shells, where they continued growing. A window on top lets researchers peek inside.\u00a0\u00a0<\/p>\n<p>\u201cTo see them all moving around in their artificial eggs was absolutely mind blowing,\u201d says Andrew Pask, the company\u2019s chief biology officer. \u201cYou really feel you can grow life outside of the womb.\u201d<\/p>\n<p>Colossal was founded in 2021 with plans to use gene editing and reproductive technology to restore extinct species, including the woolly mammoth. It\u2019s since raised more than $800 million toward what it now terms the \u201cscalable and controllable\u201d creation of animals.<\/p>\n<p>According to Pask, the egg technology could help conserve at-risk bird species. It could also play a role in a project to re-create the extinct giant moa, a flightless 12-foot-tall bird that once lived in New Zealand and laid four-liter eggs, larger than those of any living bird.<\/p>\n<p>But Colossal may be able build one that\u2019s big enough. The company provided a photograph of a prototype 3D-printed egg so large that staff have started to call it the \u201csalad spinner.\u201d<\/p>\n<p>The moa went extinct after canoes carrying the ancestors of the Maori arrived on New Zealand\u2019s South Island about 750 years ago. Archeological sites showcase the birds\u2019 bones alongside stone cutting tools\u2014clear evidence that they were hunted.<\/p>\n<p>To be clear\u2014Colossal isn\u2019t close to re-creating the moa. Before that could happen, scientists would need to study DNA data from old moa bones and insert thousands of genetic changes into the genome of an existing bird, something that\u2019s still technically difficult to do\u2014with or without an artificial egg.<\/p>\n<div class=\"wp-block-image\">\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" height=\"2000\" width=\"2667\" src=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/05\/Device_1.jpg?w=2667\" alt=\"artificial womb for chicken embryos\" class=\"wp-image-1137468\" \/>\n<div class=\"image-credit\">COLOSSAL BIOSCIENCES<\/div>\n<\/figure>\n<\/div>\n<p>Some scientists also think Colossal is taking too much credit for its artificial eggshell, which it announced in a <a href=\"https:\/\/www.youtube.com\/watch?v=UmsXdWSOK-k\">thundering YouTube video<\/a> intoning that the company has solved the \u201cimpossible question of which came first, the chicken or the egg.\u201d<\/p>\n<p>The video is pure Hollywood\u2014it\u2019s meant to be funny and exciting. But Colossal has a habit of antagonizing scientists by making false and exaggerated claims. Last year, for instance, the company said it had <a href=\"https:\/\/www.technologyreview.com\/2025\/04\/08\/1114371\/game-of-clones-colossals-new-wolves-are-cute-but-are-they-dire\/\">re-created the extinct dire wolf<\/a>\u2014a claim widely rejected by experts.\u00a0<\/p>\n<p>This time, Colossal\u2019s fluffed-up assertion of having created the \u201cfirst-ever shell-less incubation system\u201d is what\u2019s raising hackles among the small flock of scientists who\u2019ve been working on the technology for years.\u00a0<\/p>\n<p>\u201cClearly an overstatement,\u201d says Katsuya Obara, at the University of Tsukuba in Japan, who in 2024 <a href=\"https:\/\/www.nature.com\/articles\/s41598-024-72004-y\">hatched chickens from beneath transparent plastic film<\/a>. \u201cThe technology here is essentially a modification of existing methods.\u201d<\/p>\n<p>In fact, Obara notes, growing birds in artificial containers goes all the way back <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/9727359\/\">to 1998<\/a>, when another Japanese group managed to do it with quail.<\/p>\n<p>What may be an advance by Colossal is the special membrane, which lets the embryo access more oxygen. Previous systems required scientists to supplement the gas\u2014something that may not have been good for the chicks, as often some of them would fail to hatch.\u00a0<\/p>\n<p>The work on the artificial eggshell was carried out in Dallas by Colossal\u2019s exogenous development team, or Exo Dev. That group is also trying to develop artificial wombs for mammals, starting with marsupials.<\/p>\n<p>\u201cWe\u2019re looking at every single facet of what\u2019s happening during a mammalian pregnancy to unpack exactly how we then go about recapitulating that,\u201d says Pask.<\/p>\n<p>For that team, an artificial eggshell is a relatively quick and easy technical win. That\u2019s because chickens are already an example of ex utero development. After an egg is laid, a small embryo sitting on top of the yolk starts growing, drawing nutrients from the yolk, the white, and even the shell., which provides calcium. (Colossal says it has to add ground-up calcium to the artificial eggs.)<\/p>\n<div class=\"wp-block-image\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" height=\"2000\" width=\"2667\" src=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/05\/EmbryoDevelopment.jpg?w=2667\" alt=\"looking down into the artificial egg shell to see a developing chick embryo and its vascular structure\" class=\"wp-image-1137469\" \/>\n<div class=\"image-credit\">COLOSSAL BIOSCIENCES<\/div>\n<\/figure>\n<\/div>\n<p>In order to create a moa, Colossal will have to genetically alter another type of bird, changing potentially thousands of DNA letters. But so far, chickens are the only bird species that can be genetically engineered. And that\u2019s via a tricky process of editing stem cells that produce egg and sperm. Scientists have to add or delete DNA letters from these cells and then inject them back into an egg. The resulting bird will carry the genetic change in its gonads\u2014and then be able to pass it on.\u00a0<\/p>\n<p>Pask says Colossal\u2019s idea is that it could modify avian stem cells enough toproduce moa-like sperm or eggs. But then you might have the odd situation of a chicken laying an egg with a moa embryo inside it. \u201cYou would have chickens making moa egg and moa sperm. But it\u2019s still a chicken egg,\u201d he says.<\/p>\n<p>Helen Sang, a professor emeritus at the Roslin Institute in the United Kingdom, says she\u2019s not sure a moa embryo could survive on the yolk of a chicken egg, given evolutionary differences. \u201cThere are significant challenges to overcome to grow an embryo of a different species in artificial eggs,\u201d says Sang.<\/p>\n<p>Just one of those is the huge size discrepancy. The amount of yolk in a chicken egg would hardly be enough to support the much larger moa chick. Yet Pask says that is exactly where the artificial egg will come in handy.<\/p>\n<p>He says it may be possible to use a fine needle to slowly \u201cput 50 yolks together to make that yolk mass much larger.\u201d<\/p>\n<p>\u201cThe chicken egg isn\u2019t going to be big enough to support the growth of the moa through to term, to when it would normally hatch, but that\u2019s when you could then take that egg, put it into the artificial egg environment, and then scale it up in size,\u201d he says.<\/p>\n<p>So far, Pask says, the artificial egg is working well for chickens\u2014almost too well. \u201cWe hatched 26 chickens and then [our CEO] asked us to put the brakes on. We have too many chickens running around.\u201d<\/p>","protected":false},"excerpt":{"rendered":"<p>The baby chicks were shifting and starting to pip\u2014or trying to hatch. But not from an egg.\u00a0 Instead, these chickens were growing inside transparent 3D-printed plastic cups at the Dallas headquarters of Colossal Biosciences. The biotech company today claimed it has developed a \u201cfully artificial egg\u201d as part of its effort to resurrect extinct avian species, including birds like the dodo and the giant moa. But \u201cartificial eggshell\u201d would probably be a better description for the invention. It\u2019s an oval-shaped printed lattice, coated inside with a special silicone-based membrane that lets in oxygen, just as a real eggshell does.\u00a0 To generate birds, Colossal took recently laid chicken eggs and carefully poured their contents into the artificial shells, where they continued growing. A window on top lets researchers peek inside.\u00a0\u00a0 \u201cTo see them all moving around in their artificial eggs was absolutely mind blowing,\u201d says Andrew Pask, the company\u2019s chief biology officer. \u201cYou really feel you can grow life outside of the womb.\u201d Colossal was founded in 2021 with plans to use gene editing and reproductive technology to restore extinct species, including the woolly mammoth. It\u2019s since raised more than $800 million toward what it now terms the \u201cscalable and controllable\u201d creation of animals. According to Pask, the egg technology could help conserve at-risk bird species. It could also play a role in a project to re-create the extinct giant moa, a flightless 12-foot-tall bird that once lived in New Zealand and laid four-liter eggs, larger than those of any living bird. But Colossal may be able build one that\u2019s big enough. The company provided a photograph of a prototype 3D-printed egg so large that staff have started to call it the \u201csalad spinner.\u201d The moa went extinct after canoes carrying the ancestors of the Maori arrived on New Zealand\u2019s South Island about 750 years ago. Archeological sites showcase the birds\u2019 bones alongside stone cutting tools\u2014clear evidence that they were hunted. To be clear\u2014Colossal isn\u2019t close to re-creating the moa. Before that could happen, scientists would need to study DNA data from old moa bones and insert thousands of genetic changes into the genome of an existing bird, something that\u2019s still technically difficult to do\u2014with or without an artificial egg. COLOSSAL BIOSCIENCES Some scientists also think Colossal is taking too much credit for its artificial eggshell, which it announced in a thundering YouTube video intoning that the company has solved the \u201cimpossible question of which came first, the chicken or the egg.\u201d The video is pure Hollywood\u2014it\u2019s meant to be funny and exciting. But Colossal has a habit of antagonizing scientists by making false and exaggerated claims. Last year, for instance, the company said it had re-created the extinct dire wolf\u2014a claim widely rejected by experts.\u00a0 This time, Colossal\u2019s fluffed-up assertion of having created the \u201cfirst-ever shell-less incubation system\u201d is what\u2019s raising hackles among the small flock of scientists who\u2019ve been working on the technology for years.\u00a0 \u201cClearly an overstatement,\u201d says Katsuya Obara, at the University of Tsukuba in Japan, who in 2024 hatched chickens from beneath transparent plastic film. \u201cThe technology here is essentially a modification of existing methods.\u201d In fact, Obara notes, growing birds in artificial containers goes all the way back to 1998, when another Japanese group managed to do it with quail. What may be an advance by Colossal is the special membrane, which lets the embryo access more oxygen. Previous systems required scientists to supplement the gas\u2014something that may not have been good for the chicks, as often some of them would fail to hatch.\u00a0 The work on the artificial eggshell was carried out in Dallas by Colossal\u2019s exogenous development team, or Exo Dev. That group is also trying to develop artificial wombs for mammals, starting with marsupials. \u201cWe\u2019re looking at every single facet of what\u2019s happening during a mammalian pregnancy to unpack exactly how we then go about recapitulating that,\u201d says Pask. For that team, an artificial eggshell is a relatively quick and easy technical win. That\u2019s because chickens are already an example of ex utero development. After an egg is laid, a small embryo sitting on top of the yolk starts growing, drawing nutrients from the yolk, the white, and even the shell., which provides calcium. (Colossal says it has to add ground-up calcium to the artificial eggs.) COLOSSAL BIOSCIENCES In order to create a moa, Colossal will have to genetically alter another type of bird, changing potentially thousands of DNA letters. But so far, chickens are the only bird species that can be genetically engineered. And that\u2019s via a tricky process of editing stem cells that produce egg and sperm. Scientists have to add or delete DNA letters from these cells and then inject them back into an egg. The resulting bird will carry the genetic change in its gonads\u2014and then be able to pass it on.\u00a0 Pask says Colossal\u2019s idea is that it could modify avian stem cells enough toproduce moa-like sperm or eggs. But then you might have the odd situation of a chicken laying an egg with a moa embryo inside it. \u201cYou would have chickens making moa egg and moa sperm. But it\u2019s still a chicken egg,\u201d he says. Helen Sang, a professor emeritus at the Roslin Institute in the United Kingdom, says she\u2019s not sure a moa embryo could survive on the yolk of a chicken egg, given evolutionary differences. \u201cThere are significant challenges to overcome to grow an embryo of a different species in artificial eggs,\u201d says Sang. Just one of those is the huge size discrepancy. The amount of yolk in a chicken egg would hardly be enough to support the much larger moa chick. Yet Pask says that is exactly where the artificial egg will come in handy. He says it may be possible to use a fine needle to slowly \u201cput 50 yolks together to make that yolk mass much larger.\u201d \u201cThe chicken egg isn\u2019t going to be big enough to support the growth of the moa through to term, to when it<\/p>","protected":false},"author":2,"featured_media":91438,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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NU","author_link":"https:\/\/youzum.net\/zh\/members\/adminnu\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/youzum.net\/zh\/category\/ai-club\/\" rel=\"category tag\">AI<\/a> <a href=\"https:\/\/youzum.net\/zh\/category\/committee\/\" rel=\"category tag\">Committee<\/a> <a href=\"https:\/\/youzum.net\/zh\/category\/news\/\" rel=\"category tag\">News<\/a> <a href=\"https:\/\/youzum.net\/zh\/category\/uncategorized\/\" rel=\"category tag\">Uncategorized<\/a>","rttpg_excerpt":"The baby chicks were shifting and starting to pip\u2014or trying to hatch. But not from an egg.\u00a0 Instead, these chickens were growing inside transparent 3D-printed plastic cups at the Dallas headquarters of Colossal Biosciences. The biotech company today claimed it has developed a \u201cfully artificial egg\u201d as part of its effort to resurrect extinct avian&hellip;","_links":{"self":[{"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/posts\/91437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/comments?post=91437"}],"version-history":[{"count":0,"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/posts\/91437\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/media\/91438"}],"wp:attachment":[{"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/media?parent=91437"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/categories?post=91437"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/tags?post=91437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}