{"id":123026,"date":"2026-10-07T03:14:10","date_gmt":"2026-10-07T03:14:10","guid":{"rendered":"https:\/\/youzum.net\/weight-loss-drugs-show-signs-of-slowing-biological-aging-say-drugmakers\/"},"modified":"2026-10-07T03:14:10","modified_gmt":"2026-10-07T03:14:10","slug":"weight-loss-drugs-show-signs-of-slowing-biological-aging-say-drugmakers","status":"publish","type":"post","link":"https:\/\/youzum.net\/zh\/weight-loss-drugs-show-signs-of-slowing-biological-aging-say-drugmakers\/","title":{"rendered":"Weight-loss drugs show signs of slowing biological aging, say drugmakers"},"content":{"rendered":"

Popular weight-loss drugs may do more than help people shed pounds. They might also melt away the years.<\/p>\n

Drug giants Eli Lilly and Novo Nordisk say patients taking their drugs age less quickly, according to readouts from molecular \u201caging clocks.\u201d<\/p>\n

Such clocks assess a person\u2019s biological age by looking at changes to DNA that accumulate with time, or, in newer versions, by tracking levels of key proteins.<\/p>\n

Both companies found that overweight or diabetic patients taking the drugs, called GLP-1s, had reduced biological age compared to those taking a placebo, although the difference varied widely, depending on which type of clock was used, and what organ was tested.\u00a0<\/p>\n

Overall, the difference was around \u201ctwo to three years,\u201d according to Nikolaj Roed, a global project leader at Novo, who says the company has been seeing \u201cimproved biological age in our patients across trials and across different tissues.\u201d\u00a0<\/p>\n

The findings add to wide speculation among scientists that GLP-1 drugs, as they are known, are acting on basic causes of aging and might be a true longevity treatment.<\/p>\n

\u201cTwo years is a pretty strong effect, in my book,\u201d says Steve Horvath, a professor at the University of California, Los Angeles, who\u2019s credited with inventing aging clocks<\/a>. <\/em>Horvath says the emerging data could provide \u201cevidence that these GLP-1 drugs are actually what is known as geroprotectors, medications that slow or possibly even reverse biologic aging.\u201d<\/p>\n

The companies shared their findings over the weekend during Aging Research & Drug Discovery, a conference devoted to seeking scientific remedies for old age. While that quest has not yet produced any clear-cut success, some scientists now think Novo\u2019s drug semaglutide (sold under the names Ozempic and Wegovy) is coming close.<\/p>\n

\u201cIn an unhealthy population, I do think it\u2019s an anti-aging drug,\u201d says Vadim Gladyshev, a Harvard biologist who assisted Novo with its molecular measurements. \u201cBut in a healthy population, no one knows.\u201d<\/p>\n

The drugs cause weight loss by stimulating a receptor, GLP-1, that tells your brain you\u2019re not hungry. Yet real-world studies have shown much wider benefit. The drugs improve kidney function, reduce blood pressure, and even sharply cut the overall chance of death.<\/p>\n

\u201cIf the question is,\u2018Can semaglutide reach several diseases relevant to health span and aging?\u2019 we know we can say the answer is yes,\u201d said Alejandro Aguayo-Orozco, a senior scientific director at Novo, the Danish drug giant, during the meeting.<\/p>\n

The next question to answer, he said, is whether such effects are accompanied by changes to molecular measures of biological aging: \u201cWhen you intervene with semaglutide, does it actually move the clocks in any direction? And the answer is yes.\u201d\u00a0<\/p>\n

The company found that, over time, the drugs cause a wide slowdown in aging clocks\u2014as much as 4 years in the case of a clock that looks at heart proteins. \u201cI think it\u2019s pretty clear that the organ age is shifting,\u201d said Aguayo-Orozco.<\/p>\n

The studies are also a huge boost for the science of aging clocks. Although these measures reflect a person\u2019s age, it\u2019s been uncertain if they are useful as true biomarkers. Now clock makers have evidence\u00a0 that their readouts show a drop in age when people take drugs with broad, well-demonstrated benefits.\u00a0\u00a0<\/p>\n

\u201cThe clock people have been pushing for a decade to get this kind of study done,\u201d says Yuge Ji, a biologist who previously worked in the field and now runs a startup, Reflector Bio. \u201cIt\u2019s huge for them.\u201d<\/p>\n

As part of its study, Novo took blood draws from 10,052 people, half on the drug and half on a placebo. Their blood, collected at the start of the study as well as months later, was then measured with \u201cproteomic clocks,\u201d which use levels of key proteins to predict a person\u2019s age and risk of dying<\/a>.\u00a0<\/p>\n

Scientists at Eli Lilly performed similar research on their GLP-1 drug, tirzepatide, using so-called \u201cepigenetic\u201d clocks that assess age by counting accumulated changes to DNA. Lilly\u2019s study was smaller, but also found that for the most part, molecular time moved more slowly for people on the drug.\u00a0\u00a0<\/p>\n

\u201cAll the clocks are telling a consistent story that we\u2019re seeing a reduction in age,\u201d Kevin Duffin, vice president for aging research at Lilly, said during the conference. \u201cIt\u2019s not like we\u2019re going to reverse age by 30 years or something, but it\u2019s a significant reduction.\u201d<\/p>\n

The molecules have become the best selling drugs in the world,, with Lilly\u2019s tirzepatide, sold as Mounjaro for diabetes and Zepbound for obesity, topping the list with more than $36 billion in revenue to the company last year<\/a>. Novo\u2019s semaglutide, also sold under more than one name, was a close second.<\/p>\n

Alex Zhavoronkov, the founder of Insilico Medicine, and the organizer of the Boston meeting, says that extending lives by even one year across the world\u2019s population would be equal to tens of millions of lifetimes.\u00a0\u00a0<\/p>\n

Last month Zhavoronkov showed that one of his company\u2019s drugs, for a lung disease, also reversed the signals from aging clocks<\/a>. That drug is experimental, but Zhavoronkov has sought to promote the idea that humanity is entering a new era of longevity medicines. He also disclosed during the event that he has been \u201cmicrodosing\u201d the available weight-loss drugs, even though he is not overweight.<\/p>\n

\u201cI am on tirzepatide and I am an equal-opportunity injector of semaglutide as well,\u201d Zhavoronkov said.<\/p>\n

It was part of an effort to directly raise the question of whether the first mass-market anti-aging remedy is already here.<\/p>\n

\u201cDo you think a reasonable person should start taking semaglutide?\u201d he asked Aguayo-Orozco, the Novo scientist, in front of a crowded audience.<\/p>\n

\u201cI am not a physician. I cannot answer that question,\u201d Aguayo-Orozco replied.<\/p>\n

Several people cautioned that GLP-1 drugs do have side effects, including muscle loss. That is one reason they might not help most people, says Horvath, who says he isn\u2019t ready to take the drugs himself, although he\u2019s thought about it.<\/p>\n

\u201cClearly, the drugs have many benefits in obese people, but I did not yet see sufficient evidence that they will benefit skinny people,\u201d he said. \u201cI guess we will have to wait.\u201d<\/p>\n

Answers could start to emerge in a year or two. This past January, a US agency, ARPA-H, put $38 million toward a study in Texas that will attempt to determine whether semaglutide has anti-aging effects in healthy people over 60. That research will look at changes in cognition, mobility, and acuity of the senses.<\/p>\n

That project also seeks to help define a regulatory pathway for anti-aging drugs and to \u201cbuild a new therapeutic industry\u201d around longevity.<\/p>","protected":false},"excerpt":{"rendered":"

Popular weight-loss drugs may do more than help people shed pounds. They might also melt away the years. Drug giants Eli Lilly and Novo Nordisk say patients taking their drugs age less quickly, according to readouts from molecular \u201caging clocks.\u201d Such clocks assess a person\u2019s biological age by looking at changes to DNA that accumulate with time, or, in newer versions, by tracking levels of key proteins. Both companies found that overweight or diabetic patients taking the drugs, called GLP-1s, had reduced biological age compared to those taking a placebo, although the difference varied widely, depending on which type of clock was used, and what organ was tested.\u00a0 Overall, the difference was around \u201ctwo to three years,\u201d according to Nikolaj Roed, a global project leader at Novo, who says the company has been seeing \u201cimproved biological age in our patients across trials and across different tissues.\u201d\u00a0 The findings add to wide speculation among scientists that GLP-1 drugs, as they are known, are acting on basic causes of aging and might be a true longevity treatment. \u201cTwo years is a pretty strong effect, in my book,\u201d says Steve Horvath, a professor at the University of California, Los Angeles, who\u2019s credited with inventing aging clocks. Horvath says the emerging data could provide \u201cevidence that these GLP-1 drugs are actually what is known as geroprotectors, medications that slow or possibly even reverse biologic aging.\u201d The companies shared their findings over the weekend during Aging Research & Drug Discovery, a conference devoted to seeking scientific remedies for old age. While that quest has not yet produced any clear-cut success, some scientists now think Novo\u2019s drug semaglutide (sold under the names Ozempic and Wegovy) is coming close. \u201cIn an unhealthy population, I do think it\u2019s an anti-aging drug,\u201d says Vadim Gladyshev, a Harvard biologist who assisted Novo with its molecular measurements. \u201cBut in a healthy population, no one knows.\u201d The drugs cause weight loss by stimulating a receptor, GLP-1, that tells your brain you\u2019re not hungry. Yet real-world studies have shown much wider benefit. The drugs improve kidney function, reduce blood pressure, and even sharply cut the overall chance of death. \u201cIf the question is,\u2018Can semaglutide reach several diseases relevant to health span and aging?\u2019 we know we can say the answer is yes,\u201d said Alejandro Aguayo-Orozco, a senior scientific director at Novo, the Danish drug giant, during the meeting. The next question to answer, he said, is whether such effects are accompanied by changes to molecular measures of biological aging: \u201cWhen you intervene with semaglutide, does it actually move the clocks in any direction? And the answer is yes.\u201d\u00a0 The company found that, over time, the drugs cause a wide slowdown in aging clocks\u2014as much as 4 years in the case of a clock that looks at heart proteins. \u201cI think it\u2019s pretty clear that the organ age is shifting,\u201d said Aguayo-Orozco. The studies are also a huge boost for the science of aging clocks. Although these measures reflect a person\u2019s age, it\u2019s been uncertain if they are useful as true biomarkers. Now clock makers have evidence\u00a0 that their readouts show a drop in age when people take drugs with broad, well-demonstrated benefits.\u00a0\u00a0 \u201cThe clock people have been pushing for a decade to get this kind of study done,\u201d says Yuge Ji, a biologist who previously worked in the field and now runs a startup, Reflector Bio. \u201cIt\u2019s huge for them.\u201d As part of its study, Novo took blood draws from 10,052 people, half on the drug and half on a placebo. Their blood, collected at the start of the study as well as months later, was then measured with \u201cproteomic clocks,\u201d which use levels of key proteins to predict a person\u2019s age and risk of dying.\u00a0 Scientists at Eli Lilly performed similar research on their GLP-1 drug, tirzepatide, using so-called \u201cepigenetic\u201d clocks that assess age by counting accumulated changes to DNA. Lilly\u2019s study was smaller, but also found that for the most part, molecular time moved more slowly for people on the drug.\u00a0\u00a0 \u201cAll the clocks are telling a consistent story that we\u2019re seeing a reduction in age,\u201d Kevin Duffin, vice president for aging research at Lilly, said during the conference. \u201cIt\u2019s not like we\u2019re going to reverse age by 30 years or something, but it\u2019s a significant reduction.\u201d The molecules have become the best selling drugs in the world,, with Lilly\u2019s tirzepatide, sold as Mounjaro for diabetes and Zepbound for obesity, topping the list with more than $36 billion in revenue to the company last year. Novo\u2019s semaglutide, also sold under more than one name, was a close second. Alex Zhavoronkov, the founder of Insilico Medicine, and the organizer of the Boston meeting, says that extending lives by even one year across the world\u2019s population would be equal to tens of millions of lifetimes.\u00a0\u00a0 Last month Zhavoronkov showed that one of his company\u2019s drugs, for a lung disease, also reversed the signals from aging clocks. That drug is experimental, but Zhavoronkov has sought to promote the idea that humanity is entering a new era of longevity medicines. He also disclosed during the event that he has been \u201cmicrodosing\u201d the available weight-loss drugs, even though he is not overweight. \u201cI am on tirzepatide and I am an equal-opportunity injector of semaglutide as well,\u201d Zhavoronkov said. It was part of an effort to directly raise the question of whether the first mass-market anti-aging remedy is already here. \u201cDo you think a reasonable person should start taking semaglutide?\u201d he asked Aguayo-Orozco, the Novo scientist, in front of a crowded audience. \u201cI am not a physician. I cannot answer that question,\u201d Aguayo-Orozco replied. Several people cautioned that GLP-1 drugs do have side effects, including muscle loss. That is one reason they might not help most people, says Horvath, who says he isn\u2019t ready to take the drugs himself, although he\u2019s thought about it. \u201cClearly, the drugs have many benefits in obese people, but I did not yet see sufficient evidence that they will benefit skinny<\/p>","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_pvb_checkbox_block_on_post":false,"footnotes":""},"categories":[52,5,7,1],"tags":[],"class_list":["post-123026","post","type-post","status-publish","format-standard","hentry","category-ai-club","category-committee","category-news","category-uncategorized","pmpro-has-access"],"acf":[],"yoast_head":"\nWeight-loss drugs show signs of slowing biological aging, say drugmakers - YouZum<\/title>\n<meta name=\"description\" content=\"\u0e01\u0e34\u0e08\u0e01\u0e23\u0e23\u0e21\u0e40\u0e01\u0e35\u0e48\u0e22\u0e27\u0e01\u0e31\u0e1a\u0e42\u0e14\u0e23\u0e19\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/youzum.net\/zh\/weight-loss-drugs-show-signs-of-slowing-biological-aging-say-drugmakers\/\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Weight-loss drugs show signs of slowing biological aging, say drugmakers - YouZum\" \/>\n<meta property=\"og:description\" content=\"\u0e01\u0e34\u0e08\u0e01\u0e23\u0e23\u0e21\u0e40\u0e01\u0e35\u0e48\u0e22\u0e27\u0e01\u0e31\u0e1a\u0e42\u0e14\u0e23\u0e19\" \/>\n<meta property=\"og:url\" content=\"https:\/\/youzum.net\/zh\/weight-loss-drugs-show-signs-of-slowing-biological-aging-say-drugmakers\/\" \/>\n<meta property=\"og:site_name\" content=\"YouZum\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/DroneAssociationTH\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-10-07T03:14:10+00:00\" \/>\n<meta name=\"author\" content=\"admin NU\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u4f5c\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin NU\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u9884\u8ba1\u9605\u8bfb\u65f6\u95f4\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 \u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/youzum.net\/weight-loss-drugs-show-signs-of-slowing-biological-aging-say-drugmakers\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/youzum.net\/weight-loss-drugs-show-signs-of-slowing-biological-aging-say-drugmakers\/\"},\"author\":{\"name\":\"admin NU\",\"@id\":\"https:\/\/yousum.gpucore.co\/#\/schema\/person\/97fa48242daf3908e4d9a5f26f4a059c\"},\"headline\":\"Weight-loss drugs show signs of slowing biological aging, say drugmakers\",\"datePublished\":\"2026-10-07T03:14:10+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/youzum.net\/weight-loss-drugs-show-signs-of-slowing-biological-aging-say-drugmakers\/\"},\"wordCount\":1113,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/yousum.gpucore.co\/#organization\"},\"articleSection\":[\"AI\",\"Committee\",\"News\",\"Uncategorized\"],\"inLanguage\":\"zh-Hans\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/youzum.net\/weight-loss-drugs-show-signs-of-slowing-biological-aging-say-drugmakers\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/youzum.net\/weight-loss-drugs-show-signs-of-slowing-biological-aging-say-drugmakers\/\",\"url\":\"https:\/\/youzum.net\/weight-loss-drugs-show-signs-of-slowing-biological-aging-say-drugmakers\/\",\"name\":\"Weight-loss drugs show signs of slowing biological aging, say drugmakers - 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They might also melt away the years. Drug giants Eli Lilly and Novo Nordisk say patients taking their drugs age less quickly, according to readouts from molecular \u201caging clocks.\u201d Such clocks assess a person\u2019s biological age by looking at changes to DNA that accumulate…","_links":{"self":[{"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/posts\/123026","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/comments?post=123026"}],"version-history":[{"count":0,"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/posts\/123026\/revisions"}],"wp:attachment":[{"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/media?parent=123026"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/categories?post=123026"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/tags?post=123026"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}