{"id":112959,"date":"2026-08-22T00:41:41","date_gmt":"2026-08-22T00:41:41","guid":{"rendered":"https:\/\/youzum.net\/when-ai-designs-a-drug-who-gets-the-credit\/"},"modified":"2026-08-22T00:41:41","modified_gmt":"2026-08-22T00:41:41","slug":"when-ai-designs-a-drug-who-gets-the-credit","status":"publish","type":"post","link":"https:\/\/youzum.net\/zh\/when-ai-designs-a-drug-who-gets-the-credit\/","title":{"rendered":"When AI designs a drug, who gets the credit?"},"content":{"rendered":"
<\/div>\n

When the biotech company Insilico Medicine used its computer models to propose a promising drug for pulmonary fibrosis, it enthusiastically claimed in a press release that the molecule had been \u201cdiscovered by\u201d its generative AI platform.<\/p>\n

Insilico leads a pack of companies using AI to rapidly come up with drug ideas humans might never think of, potentially speeding the race to new cures. AI models are now able to generate atomic designs for drugs almost as easily as ChatGPT can write a thank-you note.<\/p>\n

However, when it came time to file for an all-important patent to protect that new chemical structure, the company made no mention of AI. Instead the patent names five humans, including CEO Alex Zhavoronkov, as the drug\u2019s \u201cinventors.\u201d<\/p>\n

The discrepancy points to a fascinating wrinkle in intellectual-property law. No matter how fundamental an AI is to a discovery, when it comes to winning rights to an invention, it\u2019s humans\u2014and only humans\u2014who can take the credit.<\/p>\n

US courts reached that conclusion after Ryan Abbott<\/a>, a partner at the LA law firm Brown, Neri, Smith & Khan, brought a pro bono test case naming an AI called DABUS as an inventor of a better food container, whose intricate geometric surface lets it transfer heat well and stack easily. Because no human contributed to the design, Abbott argued that the AI should be named the inventor.<\/p>\n

The case might have raised philosophical questions, like whether AIs deserve legal rights or what the true nature is of that eureka moment that leads to a better mousetrap. But in 2022, an appeals court in Washington, DC, said these \u201cmetaphysical matters\u201d were beside the point. Instead, it noted<\/a> that US statutes describe an inventor as an \u201cindividual,\u201d the plain meaning of which is a human being.<\/p>\n

Since machines aren\u2019t people, they can\u2019t be inventors. Case closed.<\/p>\n

\u201cThere needs to be a human inventor or there\u2019s no invention and no patent,\u201d says Sarah Korman, a patent attorney who is now chief business officer and legal officer of Isomorphic Labs, an Alphabet spinout with big ambitions for AI cures. Korman, who made her remarks at MIT Technology Review<\/em>\u2019s EmTech event last year, added that there is \u201cno doubt\u201d our laws will need to evolve to keep pace with AI.<\/p>\n

That\u2019s partly because no one is denying that AIs can<\/em> invent things. In the future, they may do so with less and less human intervention. As the US Patent and Trademark Office has itself acknowledged, \u201can AI system\u2014like other tools\u2014may perform acts that, if performed by a human, could constitute inventorship under our laws.\u201d<\/p>\n

Instead, the key question going forward may actually be whether or not any human<\/em> contributed enough to be named as an inventor. Abbott believes there could be legal challenges to AI-generated drugs, since one way to invalidate a patent is to show it has the wrong inventors listed.<\/p>\n

Abbott\u2019s worry is that if US policy excludes AI-generated outputs from protection, that could put a damper on future drug development. Already, the US Copyright Office is refusing to grant copyrights to images and text generated by AI, raising concerns<\/a> from organizations like the Motion Picture Association of America, whose members are using those tools.\u00a0<\/p>\n

The point of our intellectual-property laws is to encourage innovation, Abbott says. It\u2019s right there in Article 1 of the US Constitution, which says inventors and authors need to be given exclusive rights to their ideas, for a limited time, in order \u201cto promote the Progress of Science and the Useful Arts.\u201d<\/p>\n

Currently, the US patent office seems to be taking a don\u2019t-ask-don\u2019t-tell approach to the use of AI. Under the Biden administration, the agency published guidance to help applicants determine whether and when humans would truly qualify as co-inventors of an AI discovery. But after Trump arrived in office, it reversed course. Now the patent office says AI is merely a tool, like a calculator. No need to even mention it.<\/p>\n

You can bet that pioneering AI drug companies are keeping humans in the loop, at least for now, and documenting everything carefully. At Insilico, Zhavoronkov says, human chemists still have to synthesize the drugs, create variants, and test them on animals. \u201cThat\u2019s the person who is going to be named on the patent,\u201d he says. \u201cAnd even if you decided to completely roboticize this process, including the experiments, someone will still push the button and give the budget.\u201d<\/p>\n

Should pushing a button count as being an inventor? Abbott says that\u2019s a question for future legal cases. \u201cWhat if I asked Claude to cure cancer, and it did?\u201d he says. \u201cI think it would be inappropriate to claim that I invented that.\u201d\u00a0<\/p>\n

This article first appeared in The Checkup,\u00a0<\/em>MIT Technology Review\u2019s\u00a0weekly biotech newsletter. To receive it in your inbox every Thursday, and read articles like this first,\u00a0<\/em>sign up here<\/em><\/a>.<\/p>","protected":false},"excerpt":{"rendered":"

When the biotech company Insilico Medicine used its computer models to propose a promising drug for pulmonary fibrosis, it enthusiastically claimed in a press release that the molecule had been \u201cdiscovered by\u201d its generative AI platform. Insilico leads a pack of companies using AI to rapidly come up with drug ideas humans might never think of, potentially speeding the race to new cures. AI models are now able to generate atomic designs for drugs almost as easily as ChatGPT can write a thank-you note. However, when it came time to file for an all-important patent to protect that new chemical structure, the company made no mention of AI. Instead the patent names five humans, including CEO Alex Zhavoronkov, as the drug\u2019s \u201cinventors.\u201d The discrepancy points to a fascinating wrinkle in intellectual-property law. No matter how fundamental an AI is to a discovery, when it comes to winning rights to an invention, it\u2019s humans\u2014and only humans\u2014who can take the credit. US courts reached that conclusion after Ryan Abbott, a partner at the LA law firm Brown, Neri, Smith & Khan, brought a pro bono test case naming an AI called DABUS as an inventor of a better food container, whose intricate geometric surface lets it transfer heat well and stack easily. Because no human contributed to the design, Abbott argued that the AI should be named the inventor. The case might have raised philosophical questions, like whether AIs deserve legal rights or what the true nature is of that eureka moment that leads to a better mousetrap. But in 2022, an appeals court in Washington, DC, said these \u201cmetaphysical matters\u201d were beside the point. Instead, it noted that US statutes describe an inventor as an \u201cindividual,\u201d the plain meaning of which is a human being. Since machines aren\u2019t people, they can\u2019t be inventors. Case closed. \u201cThere needs to be a human inventor or there\u2019s no invention and no patent,\u201d says Sarah Korman, a patent attorney who is now chief business officer and legal officer of Isomorphic Labs, an Alphabet spinout with big ambitions for AI cures. Korman, who made her remarks at MIT Technology Review\u2019s EmTech event last year, added that there is \u201cno doubt\u201d our laws will need to evolve to keep pace with AI. That\u2019s partly because no one is denying that AIs can invent things. In the future, they may do so with less and less human intervention. As the US Patent and Trademark Office has itself acknowledged, \u201can AI system\u2014like other tools\u2014may perform acts that, if performed by a human, could constitute inventorship under our laws.\u201d Instead, the key question going forward may actually be whether or not any human contributed enough to be named as an inventor. Abbott believes there could be legal challenges to AI-generated drugs, since one way to invalidate a patent is to show it has the wrong inventors listed. Abbott\u2019s worry is that if US policy excludes AI-generated outputs from protection, that could put a damper on future drug development. Already, the US Copyright Office is refusing to grant copyrights to images and text generated by AI, raising concerns from organizations like the Motion Picture Association of America, whose members are using those tools.\u00a0 The point of our intellectual-property laws is to encourage innovation, Abbott says. It\u2019s right there in Article 1 of the US Constitution, which says inventors and authors need to be given exclusive rights to their ideas, for a limited time, in order \u201cto promote the Progress of Science and the Useful Arts.\u201d Currently, the US patent office seems to be taking a don\u2019t-ask-don\u2019t-tell approach to the use of AI. Under the Biden administration, the agency published guidance to help applicants determine whether and when humans would truly qualify as co-inventors of an AI discovery. But after Trump arrived in office, it reversed course. Now the patent office says AI is merely a tool, like a calculator. No need to even mention it. You can bet that pioneering AI drug companies are keeping humans in the loop, at least for now, and documenting everything carefully. At Insilico, Zhavoronkov says, human chemists still have to synthesize the drugs, create variants, and test them on animals. \u201cThat\u2019s the person who is going to be named on the patent,\u201d he says. \u201cAnd even if you decided to completely roboticize this process, including the experiments, someone will still push the button and give the budget.\u201d Should pushing a button count as being an inventor? Abbott says that\u2019s a question for future legal cases. \u201cWhat if I asked Claude to cure cancer, and it did?\u201d he says. \u201cI think it would be inappropriate to claim that I invented that.\u201d\u00a0 This article first appeared in The Checkup,\u00a0MIT Technology Review\u2019s\u00a0weekly biotech newsletter. To receive it in your inbox every Thursday, and read articles like this first,\u00a0sign up here.<\/p>","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_pvb_checkbox_block_on_post":false,"footnotes":""},"categories":[52,5,7,1],"tags":[],"class_list":["post-112959","post","type-post","status-publish","format-standard","hentry","category-ai-club","category-committee","category-news","category-uncategorized","pmpro-has-access"],"acf":[],"yoast_head":"\nWhen AI designs a drug, who gets the credit? 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