{"id":106562,"date":"2026-07-24T19:37:05","date_gmt":"2026-07-24T19:37:05","guid":{"rendered":"https:\/\/youzum.net\/the-quest-to-keep-organs-alive-outside-the-body\/"},"modified":"2026-07-24T19:37:05","modified_gmt":"2026-07-24T19:37:05","slug":"the-quest-to-keep-organs-alive-outside-the-body","status":"publish","type":"post","link":"https:\/\/youzum.net\/zh\/the-quest-to-keep-organs-alive-outside-the-body\/","title":{"rendered":"The quest to keep organs alive outside the body"},"content":{"rendered":"
<\/div>\n

This week, I covered a fascinating effort to preserve organs outside the body. There\u2019s a huge shortage of donor organs, and one of the main reasons is time\u2014they survive only a matter of hours outside the body, even when they\u2019re kept on ice.<\/p>\n

Doctors dream of organ banks\u2014stores of human organs that can be preserved for days, weeks, months, or even longer. That would allow them to run tests on organs, find the best matches for them, and transport the organs to those recipients.<\/p>\n

In new research, one team has been able to supercool the kidneys of pigs\u2014animals whose organs are of a similar size to human ones\u2014and preserve them for days. The kidneys survived being stored at \u22124 \u00b0C (25 \u00b0F) and eventually reimplanted back into pigs. And that\u2019s just the latest development in a field that is positively buzzing.<\/p>\n

It has proved super difficult to freeze organs. Once ice forms in them, they\u2019re done. The ice crystals create all kinds of damage and render the organs unusable. That hasn\u2019t stopped many researchers from trying.<\/p>\n

Some have focused on cryopreservation\u2014rapid extreme cooling that essentially leaves cells in a glasslike state. This process is now routine for eggs, sperm, and embryos, which are\u00a0cooled to \u2212196 \u00b0C in less than two seconds<\/a> and can be used even after\u00a0decades in storage.<\/a><\/p>\n

No one has managed to cryopreserve and thaw human organs for transplantation. But plenty of human bodies and brains have been stored at ultra-low temperatures in the hope that they might one day be rewarmed and brought back to life. (You can read more about why some people opt for cryonics\u00a0\u8fd9\u91cc<\/a>.)<\/p>\n

In March, I wrote about Stephen L. Coles, a gerontologist who had opted to cryopreserve his own brain. After the scientist died in 2014, his body was taken to Alcor, a cryonics facility in Arizona. A team at the facility removed Coles\u2019s head, perfused his brain with cryoprotective chemicals (which work like antifreeze), removed the brain from the skull, and cooled it to \u2212146 \u00b0C.<\/p>\n

When Coles\u2019s friend Greg Fahy, a cryobiologist,\u00a0studied pieces of his brain years later<\/a>, he found that the brain cells, which had shrunk, \u201cbounced back\u201d once they were rewarmed. But that doesn\u2019t mean the cells are alive, or that it might one day be possible to reanimate the brain. As Matthew Powell Palm of Texas A&M told me at the time: \u201cThere are so many ways those neurons could be toast.\u201d<\/p>\n

Powell Palm is working on other ways to preserve organs. It was he, along with his colleagues, who managed to store supercooled pig kidneys and successfully transplant them, in\u00a0a study described as \u201ca landmark achievement.\u201d<\/a> Those organs did better than kidneys stored on ice, he says.<\/p>\n

His approach didn\u2019t require cryoprotectants. But other teams are exploring potential chemical cocktails that might allow them to store organs at lower temperatures, potentially for longer periods of time. (More on this in The Checkup<\/em> soon!)<\/p>\n

Another way to prolong the lifespan of an organ is to use a machine that perfuses it with nutrients, mimicking what happens inside the body. Machine perfusion devices have become more commonly used over the last decade or so and are typically used to maintain livers and kidneys for up to about 24 hours.<\/p>\n

Researchers are now adapting this protocol for a growing list of organs, even\u00a0eyeballs<\/a>\u2014a recent feat that might enable whole-eye transplants. In March, I went to visit scientists in Valencia who had developed a perfusion system for uteruses. They had used their device\u2014which they nicknamed \u201cMother\u201d\u2014to\u00a0keep a human uterus alive for a day<\/a>.<\/p>\n

It\u2019s an exciting time for organ preservation. Keep an eye out for more coverage from MIT Technology Review<\/em> in the coming weeks.<\/p>\n

This article first appeared in The Checkup,\u00a0<\/em>MIT Technology Review\u2019s\u00a0weekly biotech newsletter. To receive it in your inbox every Thursday, and read articles like this first,\u00a0<\/em>sign up here<\/em><\/a>.<\/p>","protected":false},"excerpt":{"rendered":"

This week, I covered a fascinating effort to preserve organs outside the body. There\u2019s a huge shortage of donor organs, and one of the main reasons is time\u2014they survive only a matter of hours outside the body, even when they\u2019re kept on ice. Doctors dream of organ banks\u2014stores of human organs that can be preserved for days, weeks, months, or even longer. That would allow them to run tests on organs, find the best matches for them, and transport the organs to those recipients. In new research, one team has been able to supercool the kidneys of pigs\u2014animals whose organs are of a similar size to human ones\u2014and preserve them for days. The kidneys survived being stored at \u22124 \u00b0C (25 \u00b0F) and eventually reimplanted back into pigs. And that\u2019s just the latest development in a field that is positively buzzing. It has proved super difficult to freeze organs. Once ice forms in them, they\u2019re done. The ice crystals create all kinds of damage and render the organs unusable. That hasn\u2019t stopped many researchers from trying. Some have focused on cryopreservation\u2014rapid extreme cooling that essentially leaves cells in a glasslike state. This process is now routine for eggs, sperm, and embryos, which are\u00a0cooled to \u2212196 \u00b0C in less than two seconds and can be used even after\u00a0decades in storage. No one has managed to cryopreserve and thaw human organs for transplantation. But plenty of human bodies and brains have been stored at ultra-low temperatures in the hope that they might one day be rewarmed and brought back to life. (You can read more about why some people opt for cryonics\u00a0here.) In March, I wrote about Stephen L. Coles, a gerontologist who had opted to cryopreserve his own brain. After the scientist died in 2014, his body was taken to Alcor, a cryonics facility in Arizona. A team at the facility removed Coles\u2019s head, perfused his brain with cryoprotective chemicals (which work like antifreeze), removed the brain from the skull, and cooled it to \u2212146 \u00b0C. When Coles\u2019s friend Greg Fahy, a cryobiologist,\u00a0studied pieces of his brain years later, he found that the brain cells, which had shrunk, \u201cbounced back\u201d once they were rewarmed. But that doesn\u2019t mean the cells are alive, or that it might one day be possible to reanimate the brain. As Matthew Powell Palm of Texas A&M told me at the time: \u201cThere are so many ways those neurons could be toast.\u201d Powell Palm is working on other ways to preserve organs. It was he, along with his colleagues, who managed to store supercooled pig kidneys and successfully transplant them, in\u00a0a study described as \u201ca landmark achievement.\u201d Those organs did better than kidneys stored on ice, he says. His approach didn\u2019t require cryoprotectants. But other teams are exploring potential chemical cocktails that might allow them to store organs at lower temperatures, potentially for longer periods of time. (More on this in The Checkup soon!) Another way to prolong the lifespan of an organ is to use a machine that perfuses it with nutrients, mimicking what happens inside the body. Machine perfusion devices have become more commonly used over the last decade or so and are typically used to maintain livers and kidneys for up to about 24 hours. Researchers are now adapting this protocol for a growing list of organs, even\u00a0eyeballs\u2014a recent feat that might enable whole-eye transplants. In March, I went to visit scientists in Valencia who had developed a perfusion system for uteruses. They had used their device\u2014which they nicknamed \u201cMother\u201d\u2014to\u00a0keep a human uterus alive for a day. It\u2019s an exciting time for organ preservation. Keep an eye out for more coverage from MIT Technology Review in the coming weeks. This article first appeared in The Checkup,\u00a0MIT Technology Review\u2019s\u00a0weekly biotech newsletter. To receive it in your inbox every Thursday, and read articles like this first,\u00a0sign up here.<\/p>","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_pvb_checkbox_block_on_post":false,"footnotes":""},"categories":[52,5,7,1],"tags":[],"class_list":["post-106562","post","type-post","status-publish","format-standard","hentry","category-ai-club","category-committee","category-news","category-uncategorized","pmpro-has-access"],"acf":[],"yoast_head":"\nThe quest to keep organs alive outside the body - 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There\u2019s a huge shortage of donor organs, and one of the main reasons is time\u2014they survive only a matter of hours outside the body, even when they\u2019re kept on ice. Doctors dream of organ banks\u2014stores of human organs that can be preserved…","_links":{"self":[{"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/posts\/106562","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/comments?post=106562"}],"version-history":[{"count":0,"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/posts\/106562\/revisions"}],"wp:attachment":[{"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/media?parent=106562"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/categories?post=106562"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/youzum.net\/zh\/wp-json\/wp\/v2\/tags?post=106562"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}