{"id":90114,"date":"2026-05-13T16:32:27","date_gmt":"2026-05-13T16:32:27","guid":{"rendered":"https:\/\/youzum.net\/a-plan-to-make-drugs-in-orbit-is-going-commercial\/"},"modified":"2026-05-13T16:32:27","modified_gmt":"2026-05-13T16:32:27","slug":"a-plan-to-make-drugs-in-orbit-is-going-commercial","status":"publish","type":"post","link":"https:\/\/youzum.net\/ja\/a-plan-to-make-drugs-in-orbit-is-going-commercial\/","title":{"rendered":"A plan to make drugs in orbit is going commercial"},"content":{"rendered":"<div data-chronoton-summary=\"&lt;ul&gt;&lt;br&gt;&lt;li&gt;&lt;strong&gt;A big deal:&lt;\/strong&gt; Varda Space Industries says it has signed a pharmaceutical company as a commercial customer, marking what could be a landmark moment for in-orbit manufacturing.&lt;\/li&gt;&lt;br&gt;&lt;li&gt;&lt;strong&gt;Space as a lab:&lt;\/strong&gt; The bet is that microgravity causes drug molecules to crystallize into atomic arrangements impossible on Earth, potentially unlocking new versions of existing medicines.&lt;\/li&gt;&lt;br&gt;&lt;li&gt;&lt;strong&gt;Economics favor drugs:&lt;\/strong&gt; At $7,000 per kilogram to reach orbit, space manufacturing is impractical for most industries \u2014 but blockbuster drugs can be worth over $100 million per kilogram, making them a rare exception to the brutal math of rocket launches.&lt;\/li&gt;&lt;br&gt;&lt;li&gt;&lt;strong&gt;Still more experiment than factory:&lt;\/strong&gt; Despite the excitement, no product has ever been manufactured in space, brought back, and sold on Earth. &lt;\/li&gt;&lt;\/ul&gt;\" data-chronoton-post-id=\"1137153\" data-chronoton-expand-collapse=\"1\" data-chronoton-analytics-enabled=\"1\"><\/div>\n<p>Varda Space Industries, a startup that\u2019s been pitching its ability to perform drug experiments in space, says it has signed up the pharmaceutical company United Therapeutics in what may be remembered as a notable step toward in-orbit manufacturing.<\/p>\n<p>The idea of building things in outer space for use on Earth has so far been explored mostly on board the International Space Station, and only in small-scale experiments backed by governments.<\/p>\n<p>But Varda, based in El Segundo, California, is now telling drug companies it has a practical, and repeatable, way to produce novel molecules in microgravity.\u00a0<\/p>\n<p>\u201cThis is the first commercial path to products made in space,\u201d says Michael Reilly, Varda\u2019s chief strategy officer.<\/p>\n<p>The scientific idea is that chemical mixtures have different properties under weightless conditions. For instance, water will <a href=\"https:\/\/www.instagram.com\/reel\/CqatWRsA1IS\/\">hang together<\/a> in a wiggly sphere, since without gravity, surface tension is the strongest force present.<\/p>\n<p>The plan is to launch versions of United Therapeutics\u2019 drugs into orbit, where they can be allowed to form solid crystals. The hope is that in microgravity, they\u2019ll take on atomic arrangements not seen on Earth, possibly leading to new versions with improved stability or other valuable properties.<\/p>\n<p>United is led by CEO Martine Rothblatt, who worked on early\u00a0telecommunications satellites. Since then, she\u2019s built a multibillion-dollar health franchise with a succession of drugs to treat a lung disease called pulmonary arterial hypertension, which her daughter suffers from, and a subsidiary developing <a href=\"https:\/\/www.technologyreview.com\/2023\/01\/11\/1064800\/martine-rothblatt-transplantable-organs-10-breakthrough-technologies-2023\/\">genetically modified pigs as a source of organs<\/a> for transplantation.<\/p>\n<p>Rothblatt says space could be the next step if orbital conditions permit United to identify \u201ceven more amazing\u201d versions of its drugs.<\/p>\n<h3 class=\"wp-block-heading\"><strong>Space to reformulate<\/strong><\/h3>\n<p>Pharmaceutical companies often try to keep their blockbuster franchises alive by creating improved versions of drugs or reformulating them\u2014for example, making the switch from a pill to an inhaled version, as United has done with some of its products. Doing so can keep imitators at bay and create extra decades of patent protection.<\/p>\n<p>Assisting drugmakers are specialist companies, such as Halozyme and MannKind, that earn profits by helping to reformulate other companies\u2019 drugs, often taking a royalty on future sales.<\/p>\n<p>That\u2019s the business Varda has been trying to break into\u2014by using excursions into space instead of nebulizers, patches, or nanoparticles. The company was formed in 2021 by Delian Asparouhov, a partner at Peter Thiel\u2019s Founders Fund, along with Will Bruey, a former avionics engineer with Elon Musk\u2019s SpaceX who is now Varda\u2019s CEO.<\/p>\n<p>The pair\u2019s bet is that space manufacturing will become viable once rocket launches become frequent enough\u2014and cheap enough\u2014to support a business model in which raw materials are sent into orbit, processed, and then returned to Earth in a new form.<\/p>\n<p>And that\u2019s starting to happen. To get into space, Varda has been purchasing rides from SpaceX\u2014which now launches a rocket every two or three days, usually a reusable Falcon 9.\u00a0<\/p>\n<p>Those rockets have a nose cone, or payload fairing, about the size of a moving truck that gets filled with satellites or instruments, which are then released into orbit.<\/p>\n<p>Starting in 2023, Varda began sending up small satellites that have a boulder-size capsule attached. The capsule contains equipment to carry out experiments, and it can detach and fall back to Earth, entering the atmosphere at a speed of around Mach 25 before slowing via air resistance and eventually drifting to land with a parachute. (Varda lands its craft in the Australian outback.)<\/p>\n<p>That speedy reentry has also drawn interest from the US military, including the Air Force, which has paid Varda to fly instruments and take measurements relevant to hypersonic missile technology. Of the six craft Varda has paid to put into orbit so far, half have been dedicated to military research and half carried drug-related demonstrations.\u00a0<\/p>\n<p>At Varda, such \u201cdual use\u201d of technology is accepted as part of being in the space business, which remains reliant on government support. The company\u2019s founders say Varda may be the only company that employs hypersonic engineers and pharmaceutical chemists under the same roof.<\/p>\n<figure class=\"wp-block-video\"><video height=\"1080\" width=\"1920\" controls src=\"https:\/\/wp.technologyreview.com\/wp-content\/uploads\/2026\/05\/260511-drug-manufacturing-space-embed.mov\" preload=\"none\"><\/video><figcaption class=\"wp-element-caption\">At Varda\u2019s headquarters, drug samples are loaded into a spinning arm that creates extra-high g-forces. While that\u2019s the opposite of microgravity, increased weight can provide clues into whether a drug will act differently under new conditions.<\/figcaption><div class=\"video-credit\">COURTESY VARDA<\/div>\n<\/figure>\n<h3 class=\"wp-block-heading\"><strong>Launching industries<\/strong><\/h3>\n<p>Actual space manufacturing still remains mostly an aspirational project. In 2021, Jeff Bezos, after his first trip aloft in a rocket, suggested that polluting industries should be moved beyond the atmosphere. \u201cWe need to take all heavy industry, all polluting industry, and move it into space. And keep Earth as this beautiful gem of a planet that it is,\u201d he <a href=\"https:\/\/www.ms.now\/stephanie-ruhle\/watch\/jeff-bezos-and-brother-mark-speak-to-msnbc-after-successful-blue-origin-flight-117068357904\">told MSNBC<\/a>.<\/p>\n<p>Weight is the big obstacle to such dreams. It still costs around $7,000 to launch a single kilogram of payload into orbit, which makes it impractical to, say, send cotton into space to be dyed there, or even to launch the acids and solvents needed to make a semiconductor chip.<\/p>\n<p>But drugs may be among the few exceptions to this economic rule, since pound for pound, they can be as valuable as rare radioactive isotopes and fine-cut diamonds.<\/p>\n<p>For instance, just one kilogram of the weight-loss drug Ozempic is worth more than $100 million at retail. (The reason your Ozempic bill is only $1,000 a month is that\u00a0minute quantities of the active ingredient are present in the shots.)<\/p>\n<p>That\u2019s why Varda thinks it may eventually be able to manufacture drugs in orbit. However, its effort with United is more of a flying experiment to learn whether the company\u2019s lung medicines will crystallize differently in microgravity.\u00a0\u00a0<\/p>\n<p>The terms of the deal between Varda and United aren\u2019t public, and the companies haven\u2019t said which specific drugs the collaboration will study. But Rothblatt did confirm that United is paying Varda to help it identify new crystal forms of its drugs (also called polymorphs), which it hopes could have improved properties.<\/p>\n<p>\u201cOne has to do the experiment to find out if that is so. The first part of the experiment is to see what polymorphs of these molecules can be made without the influence of gravity,\u201d she says. \u201cThen, once we have those polymorphs, we will test them.\u201d\u00a0<\/p>\n<p>There is good evidence that crystals form differently in space. For instance, in 2017 the pharmaceutical giant Merck sent samples of its cancer immunotherapy drug Keytruda to the International Space Station, where it was found to form crystals of <a href=\"https:\/\/www.nature.com\/articles\/s41526-019-0090-3\">a single size<\/a>. On Earth, the drug tended to form two different sizes at once.<\/p>\n<p>That experiment offered clues <a href=\"https:\/\/www.nasa.gov\/missions\/station\/iss-research\/crystallizing-proteins-in-space-helping-to-identify-potential-treatments-for-diseases\">for how to formulate the drug as a shot<\/a> instead of administering it intravenously. Still, when Merck introduced a Keytruda injection last year, it ended up using a different approach. That means there\u2019s still no straight-line connection between orbital discoveries and any drug here on Earth. Actual space factories are another step further from reality.\u00a0<\/p>\n<p>\u201cWe\u2019ve been learning from space for years, but I can\u2019t name anything manufactured in space, brought down to Earth, and sold,\u201d says Reilly. \u201cSo that is a first\u2014or it will be a first.\u201d<\/p>\n<p>Reilly says that Varda anticipates launching United Therapeutics\u2019 drugs into orbit sometime early next year.\u00a0<\/p>","protected":false},"excerpt":{"rendered":"<p>Varda Space Industries, a startup that\u2019s been pitching its ability to perform drug experiments in space, says it has signed up the pharmaceutical company United Therapeutics in what may be remembered as a notable step toward in-orbit manufacturing. The idea of building things in outer space for use on Earth has so far been explored mostly on board the International Space Station, and only in small-scale experiments backed by governments. But Varda, based in El Segundo, California, is now telling drug companies it has a practical, and repeatable, way to produce novel molecules in microgravity.\u00a0 \u201cThis is the first commercial path to products made in space,\u201d says Michael Reilly, Varda\u2019s chief strategy officer. The scientific idea is that chemical mixtures have different properties under weightless conditions. For instance, water will hang together in a wiggly sphere, since without gravity, surface tension is the strongest force present. The plan is to launch versions of United Therapeutics\u2019 drugs into orbit, where they can be allowed to form solid crystals. The hope is that in microgravity, they\u2019ll take on atomic arrangements not seen on Earth, possibly leading to new versions with improved stability or other valuable properties. United is led by CEO Martine Rothblatt, who worked on early\u00a0telecommunications satellites. Since then, she\u2019s built a multibillion-dollar health franchise with a succession of drugs to treat a lung disease called pulmonary arterial hypertension, which her daughter suffers from, and a subsidiary developing genetically modified pigs as a source of organs for transplantation. Rothblatt says space could be the next step if orbital conditions permit United to identify \u201ceven more amazing\u201d versions of its drugs. Space to reformulate Pharmaceutical companies often try to keep their blockbuster franchises alive by creating improved versions of drugs or reformulating them\u2014for example, making the switch from a pill to an inhaled version, as United has done with some of its products. Doing so can keep imitators at bay and create extra decades of patent protection. Assisting drugmakers are specialist companies, such as Halozyme and MannKind, that earn profits by helping to reformulate other companies\u2019 drugs, often taking a royalty on future sales. That\u2019s the business Varda has been trying to break into\u2014by using excursions into space instead of nebulizers, patches, or nanoparticles. The company was formed in 2021 by Delian Asparouhov, a partner at Peter Thiel\u2019s Founders Fund, along with Will Bruey, a former avionics engineer with Elon Musk\u2019s SpaceX who is now Varda\u2019s CEO. The pair\u2019s bet is that space manufacturing will become viable once rocket launches become frequent enough\u2014and cheap enough\u2014to support a business model in which raw materials are sent into orbit, processed, and then returned to Earth in a new form. And that\u2019s starting to happen. To get into space, Varda has been purchasing rides from SpaceX\u2014which now launches a rocket every two or three days, usually a reusable Falcon 9.\u00a0 Those rockets have a nose cone, or payload fairing, about the size of a moving truck that gets filled with satellites or instruments, which are then released into orbit. Starting in 2023, Varda began sending up small satellites that have a boulder-size capsule attached. The capsule contains equipment to carry out experiments, and it can detach and fall back to Earth, entering the atmosphere at a speed of around Mach 25 before slowing via air resistance and eventually drifting to land with a parachute. (Varda lands its craft in the Australian outback.) That speedy reentry has also drawn interest from the US military, including the Air Force, which has paid Varda to fly instruments and take measurements relevant to hypersonic missile technology. Of the six craft Varda has paid to put into orbit so far, half have been dedicated to military research and half carried drug-related demonstrations.\u00a0 At Varda, such \u201cdual use\u201d of technology is accepted as part of being in the space business, which remains reliant on government support. The company\u2019s founders say Varda may be the only company that employs hypersonic engineers and pharmaceutical chemists under the same roof. At Varda\u2019s headquarters, drug samples are loaded into a spinning arm that creates extra-high g-forces. While that\u2019s the opposite of microgravity, increased weight can provide clues into whether a drug will act differently under new conditions.COURTESY VARDA Launching industries Actual space manufacturing still remains mostly an aspirational project. In 2021, Jeff Bezos, after his first trip aloft in a rocket, suggested that polluting industries should be moved beyond the atmosphere. \u201cWe need to take all heavy industry, all polluting industry, and move it into space. And keep Earth as this beautiful gem of a planet that it is,\u201d he told MSNBC. Weight is the big obstacle to such dreams. It still costs around $7,000 to launch a single kilogram of payload into orbit, which makes it impractical to, say, send cotton into space to be dyed there, or even to launch the acids and solvents needed to make a semiconductor chip. But drugs may be among the few exceptions to this economic rule, since pound for pound, they can be as valuable as rare radioactive isotopes and fine-cut diamonds. For instance, just one kilogram of the weight-loss drug Ozempic is worth more than $100 million at retail. (The reason your Ozempic bill is only $1,000 a month is that\u00a0minute quantities of the active ingredient are present in the shots.) That\u2019s why Varda thinks it may eventually be able to manufacture drugs in orbit. However, its effort with United is more of a flying experiment to learn whether the company\u2019s lung medicines will crystallize differently in microgravity.\u00a0\u00a0 The terms of the deal between Varda and United aren\u2019t public, and the companies haven\u2019t said which specific drugs the collaboration will study. But Rothblatt did confirm that United is paying Varda to help it identify new crystal forms of its drugs (also called polymorphs), which it hopes could have improved properties. \u201cOne has to do the experiment to find out if that is so. The first part of the experiment is to see what polymorphs of<\/p>","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_pvb_checkbox_block_on_post":false,"footnotes":""},"categories":[52,5,7,1],"tags":[],"class_list":["post-90114","post","type-post","status-publish","format-standard","hentry","category-ai-club","category-committee","category-news","category-uncategorized","pmpro-has-access"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.3 - 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