{"id":97580,"date":"2026-06-15T17:59:53","date_gmt":"2026-06-15T17:59:53","guid":{"rendered":"https:\/\/youzum.net\/this-man-with-als-is-the-first-power-user-of-a-brain-implant-that-lets-him-speak\/"},"modified":"2026-06-15T17:59:53","modified_gmt":"2026-06-15T17:59:53","slug":"this-man-with-als-is-the-first-power-user-of-a-brain-implant-that-lets-him-speak","status":"publish","type":"post","link":"https:\/\/youzum.net\/fr\/this-man-with-als-is-the-first-power-user-of-a-brain-implant-that-lets-him-speak\/","title":{"rendered":"This man with ALS is \u201cthe first power user\u201d of a brain implant that lets him speak"},"content":{"rendered":"<div data-chronoton-summary=\"&lt;ul&gt;&lt;li&gt;&lt;strong&gt;First long-term &quot;power user&quot; of a speech implant:&lt;\/strong&gt; Casey Harrell, paralyzed by ALS, has logged over 3,800 hours using a brain-computer interface at home \u2014 far beyond what any previous user has achieved \u2014 communicating with 99% accuracy across a 125,000-word vocabulary.&lt;\/li&gt;&lt;li&gt;&lt;strong&gt;Growing independence changes everything:&lt;\/strong&gt; Early on, researchers had to physically connect Harrell to the device themselves. Now his care partner handles it, meaning he wakes up, gets plugged in, and simply gets on with his day.&lt;\/li&gt;&lt;li&gt;&lt;strong&gt;More than communication:&lt;\/strong&gt; Harrell uses the implant to surf the web, send emails, and continue his career as an environmental activist \u2014 and a profanity filter lets him read bedtime stories to his seven-year-old daughter.&lt;\/li&gt;&lt;li&gt;&lt;strong&gt;The holy grail, with caveats:&lt;\/strong&gt; Experts call long-term, independent BCI use a landmark achievement, but warn results may vary \u2014 brain degeneration, scar tissue, and many patients' reluctance to undergo invasive surgery remain real obstacles to wider adoption.&lt;\/li&gt;&lt;\/ul&gt;\" data-chronoton-post-id=\"1138953\" data-chronoton-expand-collapse=\"1\" data-chronoton-analytics-enabled=\"1\"><\/div>\n<p>Casey Harrell has had a set of electrodes embedded in his brain for almost three years. Harrell, who has amyotrophic lateral sclerosis (ALS) and is paralyzed, first used his brain-computer interface (BCI) to \u201cspeak\u201d sentences with the help of a research team in 2023.<\/p>\n<p>Since then, Harrell has clocked thousands of hours of use. He can use the device largely independently, once he\u2019s been \u201cplugged in\u201d with the help of a carer. His team has added new features to it, and Harrell also uses it to surf the web and perform his job.<\/p>\n<p>\u201cLiving with a disease like ALS, you are supposed to have diminished dreams. I do not,\u201d Harrell tells <em>MIT Technology Review<\/em>. \u201cAny one of these things would be an absolute godsend of improvement. To have all of them, and many, many more, is truly revolutionary.\u201d\u00a0<\/p>\n<p>Within the first 22.6 months after the device was implanted, Harrell had used it for more than 3,800 hours at home without any researchers present, the team reported today in the journal <a href=\"https:\/\/www.nature.com\/articles\/s41591-026-04414-6\"><em>Nature Medicine<\/em><\/a>. \u201cHe\u2019s the first power user of a speech BCI,\u201d says team member Sergey Stavisky, a neuroengineer at the University of California, Davis.<\/p>\n<h3 class=\"wp-block-heading\">Decoding speech<\/h3>\n<p>Three years ago, Harrell entrusted David Brandman, an associate professor of neurological surgery at the University of California, Davis, and his colleagues with his brain. Harrell, who was 45 at the time, had already been diagnosed with ALS, a degenerative disease that robs people of the use of their muscles.<\/p>\n<p>Harrell was dependent on others to control his wheelchair and to dress and feed him. He had difficulty speaking; people struggled to understand what he was saying. Then Brandman and his colleagues asked if he\u2019d like to <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT00912041\">trial a brain implant<\/a> that might help him communicate. \u201cThe industry was [on the] cusp of a transformation, and I wanted to be part of it,\u201d says Harrell. He signed up.<\/p>\n<p>In July 2023, during a five-hour operation, doctors implanted four arrays of 64 electrodes each into his brain. Each pair of arrays was wired to a \u201cpedestal\u201d connection point\u2014creating two docking locations on the exterior of his skull to connect the electrodes to a computer.<\/p>\n<p>The team had long been working on developing algorithms to decode brain activity into speech. Their system works by recording activity from the speech motor cortex\u2014a region of the brain responsible for the movements that allow us to speak.<\/p>\n<p>\u201cThere are 39 phonemes that make up all the sounds in the [American] English language,\u201d says Nicholas Card, a neuroengineer at UC Davis and member of the team. Mapping neural activity related to producing each of those phonemes can allow the team to create a personalized speech decoder and software that can \u201cspeak\u201d those words. \u201cWe first go from brain data to phonemes, and then from phonemes to words,\u201d he says.<\/p>\n<p>They started using the device around a month after the surgery. The team <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2314132#ca1\">got Harrell\u2019s speech decoder working on the first day<\/a>, says Card. On that day in August, Harrell used the device to speak with a 50-word vocabulary, and 99.6% of the words were as he\u2019d intended. That vocabulary was later expanded to 125,000 words with 97.5% accuracy.<\/p>\n<p>At the time, it was unclear how long the device might last. Brain-computer interfaces are still new\u2014not many people have had them implanted for long periods of time. Scar tissue can form around electrodes in a person\u2019s brain, interfering with their ability to pick up neural activity, for example. But that doesn\u2019t seem to be the case for Harrell.<\/p>\n<h3 class=\"wp-block-heading\">Power user<\/h3>\n<p>In another advance, Harrell is now able to use the device more independently. In 2023, members of the research team would have to visit Harrell at his home and physically connect and disconnect him from the device on the days he wanted to use it. Not anymore. The team has since automated more of the system\u2014today, Harrell\u2019s care partner can don and doff it for him. \u201cHe\u2019ll wake up, get plugged in, and just get going,\u201d says Stavisky.<\/p>\n<p>This is important, says Mariska Vansteesel, a BCI researcher at Utrecht Medical Center who was not involved in the trial. \u201cFor these technologies to be relevant for patients, we really need to test them in settings in which they will eventually be used \u2026 to demonstrate that it has value, that it\u2019s usable, and that it functions well without the constant involvement of a research team,\u201d she says.<\/p>\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\">\n<div class=\"wp-block-embed__wrapper\">\n<\/div><figcaption class=\"wp-element-caption\">Casey Harrell uses his BCI to speak in \u201cprivate mode.\u201d<\/figcaption><\/figure>\n<p>The team has also worked to improve the system itself. It is now 99% accurate, says Stavisky. Harrell can also control a cursor\u2014a game changer that enables him to use his personal computer to send text messages and emails, surf the web, and keep up with his job as an environmental activist.<\/p>\n<p>Over the years, the team has updated the system to accommodate specific requests from Harrell. He is now able to switch on a \u201cprivacy mode\u201d\u2014when active, any decoded text will be automatically deleted. He can also opt to use a \u201cprofanity filter\u201d while he\u2019s talking to his young daughter.<\/p>\n<p>\u201cWe have been able to add on to the software side of the device \u2026 improving the accuracy and adding more bells and whistles to enable me to be more independent when using the device,\u201d says Harrell. \u201cWe are making the road as we walk it, or roll it, so to speak.\u201d<\/p>\n<h3 class=\"wp-block-heading\">Nothing short of revolutionary<\/h3>\n<p>Vansteesel cautions that while the device is working well for Harrell, there\u2019s no guarantee it will work as well, or as long, for other people with ALS. Over the last decade, she has worked with a woman with ALS who used a fully implanted device to communicate using \u201cbrain clicks\u201d\u2014cursor clicks made using brain activity. The woman used her BCI for seven years, but it stopped working toward the end of that period, <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2314598\">apparently due to brain degeneration<\/a>.<\/p>\n<p>At any rate, not everyone with ALS will be willing to undergo invasive brain surgery, says Jane Huggins, who is developing noninvasive BCIs at the University of Michigan and was not involved in the trial. \u201cLong-term, independent use with efficient and accurate communication is kind of the holy grail of BCI,\u201d she says. \u201cBut we have been finding <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3286341\/\">a consistent aversion to hospital stays<\/a> among people with progressive conditions like ALS.\u201d<\/p>\n<p>Harrell, however, calls the device \u201cnothing short of revolutionary.\u201d \u201cThis has allowed me to keep working and earn money and insurance for my family. This is reconnecting me with friends and family who are too shy or too afraid to come over and not be able to understand me,\u201d Harrell says. \u201cWith my seven-year-old daughter, I am able to create a bond that I wasn\u2019t before able to forge. Now I can read to them and help them sharpen their own reading skills. By doing so, I am able to share the responsibility of parenting with my wife, who does so much caregiving for me and also our daughter.\u201d<\/p>\n<p>Stavisky and his colleagues hope to improve the device further still. \u201cWe\u2019re never satisfied,\u201d he says. One aim is to eventually restore Harrell\u2019s \u201cfull voice.\u201d They are working on a \u201cbrain-to-voice\u201d system that could directly decode brain activity to a speaking voice, complete with natural-sounding cadence, inflection and intonation\u2014a voice that could sound happy, angry, or sarcastic, for example.<\/p>\n<p>\u201cI was quietly confident that I could get some personal benefit from the system,\u201d says Harrell. \u201cNever in a million years would I think that I would achieve this much.\u201d\u00a0<\/p>","protected":false},"excerpt":{"rendered":"<p>Casey Harrell has had a set of electrodes embedded in his brain for almost three years. Harrell, who has amyotrophic lateral sclerosis (ALS) and is paralyzed, first used his brain-computer interface (BCI) to \u201cspeak\u201d sentences with the help of a research team in 2023. Since then, Harrell has clocked thousands of hours of use. He can use the device largely independently, once he\u2019s been \u201cplugged in\u201d with the help of a carer. His team has added new features to it, and Harrell also uses it to surf the web and perform his job. \u201cLiving with a disease like ALS, you are supposed to have diminished dreams. I do not,\u201d Harrell tells MIT Technology Review. \u201cAny one of these things would be an absolute godsend of improvement. To have all of them, and many, many more, is truly revolutionary.\u201d\u00a0 Within the first 22.6 months after the device was implanted, Harrell had used it for more than 3,800 hours at home without any researchers present, the team reported today in the journal Nature Medicine. \u201cHe\u2019s the first power user of a speech BCI,\u201d says team member Sergey Stavisky, a neuroengineer at the University of California, Davis. Decoding speech Three years ago, Harrell entrusted David Brandman, an associate professor of neurological surgery at the University of California, Davis, and his colleagues with his brain. Harrell, who was 45 at the time, had already been diagnosed with ALS, a degenerative disease that robs people of the use of their muscles. Harrell was dependent on others to control his wheelchair and to dress and feed him. He had difficulty speaking; people struggled to understand what he was saying. Then Brandman and his colleagues asked if he\u2019d like to trial a brain implant that might help him communicate. \u201cThe industry was [on the] cusp of a transformation, and I wanted to be part of it,\u201d says Harrell. He signed up. In July 2023, during a five-hour operation, doctors implanted four arrays of 64 electrodes each into his brain. Each pair of arrays was wired to a \u201cpedestal\u201d connection point\u2014creating two docking locations on the exterior of his skull to connect the electrodes to a computer. The team had long been working on developing algorithms to decode brain activity into speech. Their system works by recording activity from the speech motor cortex\u2014a region of the brain responsible for the movements that allow us to speak. \u201cThere are 39 phonemes that make up all the sounds in the [American] English language,\u201d says Nicholas Card, a neuroengineer at UC Davis and member of the team. Mapping neural activity related to producing each of those phonemes can allow the team to create a personalized speech decoder and software that can \u201cspeak\u201d those words. \u201cWe first go from brain data to phonemes, and then from phonemes to words,\u201d he says. They started using the device around a month after the surgery. The team got Harrell\u2019s speech decoder working on the first day, says Card. On that day in August, Harrell used the device to speak with a 50-word vocabulary, and 99.6% of the words were as he\u2019d intended. That vocabulary was later expanded to 125,000 words with 97.5% accuracy. At the time, it was unclear how long the device might last. Brain-computer interfaces are still new\u2014not many people have had them implanted for long periods of time. Scar tissue can form around electrodes in a person\u2019s brain, interfering with their ability to pick up neural activity, for example. But that doesn\u2019t seem to be the case for Harrell. Power user In another advance, Harrell is now able to use the device more independently. In 2023, members of the research team would have to visit Harrell at his home and physically connect and disconnect him from the device on the days he wanted to use it. Not anymore. The team has since automated more of the system\u2014today, Harrell\u2019s care partner can don and doff it for him. \u201cHe\u2019ll wake up, get plugged in, and just get going,\u201d says Stavisky. This is important, says Mariska Vansteesel, a BCI researcher at Utrecht Medical Center who was not involved in the trial. \u201cFor these technologies to be relevant for patients, we really need to test them in settings in which they will eventually be used \u2026 to demonstrate that it has value, that it\u2019s usable, and that it functions well without the constant involvement of a research team,\u201d she says. Casey Harrell uses his BCI to speak in \u201cprivate mode.\u201d The team has also worked to improve the system itself. It is now 99% accurate, says Stavisky. Harrell can also control a cursor\u2014a game changer that enables him to use his personal computer to send text messages and emails, surf the web, and keep up with his job as an environmental activist. Over the years, the team has updated the system to accommodate specific requests from Harrell. He is now able to switch on a \u201cprivacy mode\u201d\u2014when active, any decoded text will be automatically deleted. He can also opt to use a \u201cprofanity filter\u201d while he\u2019s talking to his young daughter. \u201cWe have been able to add on to the software side of the device \u2026 improving the accuracy and adding more bells and whistles to enable me to be more independent when using the device,\u201d says Harrell. \u201cWe are making the road as we walk it, or roll it, so to speak.\u201d Nothing short of revolutionary Vansteesel cautions that while the device is working well for Harrell, there\u2019s no guarantee it will work as well, or as long, for other people with ALS. Over the last decade, she has worked with a woman with ALS who used a fully implanted device to communicate using \u201cbrain clicks\u201d\u2014cursor clicks made using brain activity. The woman used her BCI for seven years, but it stopped working toward the end of that period, apparently due to brain degeneration. At any rate, not everyone with ALS will be willing to undergo invasive brain surgery, says Jane Huggins, who<\/p>","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_pvb_checkbox_block_on_post":false,"footnotes":""},"categories":[52,5,7,1],"tags":[],"class_list":["post-97580","post","type-post","status-publish","format-standard","hentry","category-ai-club","category-committee","category-news","category-uncategorized","pmpro-has-access"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.3 - 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