{"id":118315,"date":"2026-09-17T01:49:45","date_gmt":"2026-09-17T01:49:45","guid":{"rendered":"https:\/\/youzum.net\/meet-a-mouse-whose-brain-cortex-is-made-up-of-human-cells\/"},"modified":"2026-09-17T01:49:45","modified_gmt":"2026-09-17T01:49:45","slug":"meet-a-mouse-whose-brain-cortex-is-made-up-of-human-cells","status":"publish","type":"post","link":"https:\/\/youzum.net\/es\/meet-a-mouse-whose-brain-cortex-is-made-up-of-human-cells\/","title":{"rendered":"Meet a mouse whose brain cortex is made up of human cells"},"content":{"rendered":"
<\/div>\n

Multiple cameras tracked a mouse as it wandered around a small arena. A computer charted its position and speed, leaving Pong-like traces on a monitor.\u00a0<\/p>\n

The reason to watch this rodent so carefully? Nearly half its brain volume had been replaced with human cells.<\/p>\n

The effort to mix the brain tissues of distant species is being reported today in the journal Nature<\/em> by a team at Stanford University, led by neuroscientist Sergiu Pa\u0219ca.\u00a0<\/p>\n

Pa\u0219ca\u2019s group previously showed that human brain \u201corganoids\u201d\u2014small blobs of neural tissue\u2014could survive, and even function, after being injected into the heads of baby rodents<\/a>.<\/p>\n

Now, Pa\u0219ca has taken things a step further by genetically modifying mice so their brains don\u2019t fully develop in the first place. These modified mice are missing most cells of both the cortex and the hippocampus, two key brain areas.<\/p>\n

That creates much more room for the human cells to take hold, he says. \u201cHuman cells that are placed in these animals will divide, will grow, and within a few weeks to a few months they will take most of that space,\u201d he says. Pa\u0219ca says one surprising discovery is that the mice lacking brain tissue seemed fairly normal\u2014they walked around and squeaked. But they did have memory problems. In a maze test, they couldn\u2019t remember what parts they\u2019d explored.\u00a0<\/p>\n

The mice with the added human cells, by contrast, performed better on the maze test. That means the human tissue is playing some role in the animals\u2019 cognition.<\/p>\n

Pa\u0219ca believes what he is calling \u201cxenocortical mice\u201d could be useful in studying brain injuries. However, the report is also a dramatic demonstration of \u201cthe combined power of genetic engineering and stem-cell technology to reshape biology,\u201d says Carsten Charlesworth, a scientist who works in a different Stanford lab and was not involved in the research.<\/p>\n

Already, brain organoids are being tested in labs to see if they can be connected to computers<\/a> to play video games. Other scientists have proposed using them like replacement parts to treat stroke victims.\u00a0<\/p>\n

\u201cWhat\u2019s most remarkable to me is the extent to which human neural tissue introduced after birth grew and connected with the mouse nervous system across a species barrier,\u201d says Charlesworth. \u201cAs these technologies advance, they\u2019ll increasingly force us to challenge our traditional assumptions.\u201d<\/p>\n

Last year, Pa\u0219ca convened a group of ethics experts<\/a> to study the implications of neural organoid technology, including the odds that an animal could develop human consciousness and the risk that \u201corganoid therapy clinics\u201d might offer scam treatments to desperate patients.<\/p>\n

For now, he says, he\u2019s not concerned that the rodents have any type of human cognitive capacities. That is because their brains are relatively tiny and the evolutionary distance between man and mouse is so great.\u00a0<\/p>\n

But that\u2019s also why Pa\u0219ca says this type of experiment should not be carried out on higher species: They could end up with large volumes of functioning human brain tissue, potentially blurring the cognitive boundaries between people and animals.\u00a0<\/p>\n

Pa\u0219ca specifically cautioned against adding human brain organoids to a monkey engineered to lack a cortex.<\/p>\n

\u201cOne of the things that I see as a very clear red line is doing this experiment in a primate,\u201d he says. \u201cI don\u2019t think that is justified at this point in any way.\u201d<\/p>","protected":false},"excerpt":{"rendered":"

Multiple cameras tracked a mouse as it wandered around a small arena. A computer charted its position and speed, leaving Pong-like traces on a monitor.\u00a0 The reason to watch this rodent so carefully? Nearly half its brain volume had been replaced with human cells. The effort to mix the brain tissues of distant species is being reported today in the journal Nature by a team at Stanford University, led by neuroscientist Sergiu Pa\u0219ca.\u00a0 Pa\u0219ca\u2019s group previously showed that human brain \u201corganoids\u201d\u2014small blobs of neural tissue\u2014could survive, and even function, after being injected into the heads of baby rodents. Now, Pa\u0219ca has taken things a step further by genetically modifying mice so their brains don\u2019t fully develop in the first place. These modified mice are missing most cells of both the cortex and the hippocampus, two key brain areas. That creates much more room for the human cells to take hold, he says. \u201cHuman cells that are placed in these animals will divide, will grow, and within a few weeks to a few months they will take most of that space,\u201d he says. Pa\u0219ca says one surprising discovery is that the mice lacking brain tissue seemed fairly normal\u2014they walked around and squeaked. But they did have memory problems. In a maze test, they couldn\u2019t remember what parts they\u2019d explored.\u00a0 The mice with the added human cells, by contrast, performed better on the maze test. That means the human tissue is playing some role in the animals\u2019 cognition. Pa\u0219ca believes what he is calling \u201cxenocortical mice\u201d could be useful in studying brain injuries. However, the report is also a dramatic demonstration of \u201cthe combined power of genetic engineering and stem-cell technology to reshape biology,\u201d says Carsten Charlesworth, a scientist who works in a different Stanford lab and was not involved in the research. Already, brain organoids are being tested in labs to see if they can be connected to computers to play video games. Other scientists have proposed using them like replacement parts to treat stroke victims.\u00a0 \u201cWhat\u2019s most remarkable to me is the extent to which human neural tissue introduced after birth grew and connected with the mouse nervous system across a species barrier,\u201d says Charlesworth. \u201cAs these technologies advance, they\u2019ll increasingly force us to challenge our traditional assumptions.\u201d Last year, Pa\u0219ca convened a group of ethics experts to study the implications of neural organoid technology, including the odds that an animal could develop human consciousness and the risk that \u201corganoid therapy clinics\u201d might offer scam treatments to desperate patients. For now, he says, he\u2019s not concerned that the rodents have any type of human cognitive capacities. That is because their brains are relatively tiny and the evolutionary distance between man and mouse is so great.\u00a0 But that\u2019s also why Pa\u0219ca says this type of experiment should not be carried out on higher species: They could end up with large volumes of functioning human brain tissue, potentially blurring the cognitive boundaries between people and animals.\u00a0 Pa\u0219ca specifically cautioned against adding human brain organoids to a monkey engineered to lack a cortex. \u201cOne of the things that I see as a very clear red line is doing this experiment in a primate,\u201d he says. \u201cI don\u2019t think that is justified at this point in any way.\u201d<\/p>","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"pmpro_default_level":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_pvb_checkbox_block_on_post":false,"footnotes":""},"categories":[52,5,7,1],"tags":[],"class_list":["post-118315","post","type-post","status-publish","format-standard","hentry","category-ai-club","category-committee","category-news","category-uncategorized","pmpro-has-access"],"acf":[],"yoast_head":"\nMeet a mouse whose brain cortex is made up of human cells - 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A computer charted its position and speed, leaving Pong-like traces on a monitor.\u00a0 The reason to watch this rodent so carefully? Nearly half its brain volume had been replaced with human cells. The effort to mix the brain tissues of distant species is…","_links":{"self":[{"href":"https:\/\/youzum.net\/es\/wp-json\/wp\/v2\/posts\/118315","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/youzum.net\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/youzum.net\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/youzum.net\/es\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/youzum.net\/es\/wp-json\/wp\/v2\/comments?post=118315"}],"version-history":[{"count":0,"href":"https:\/\/youzum.net\/es\/wp-json\/wp\/v2\/posts\/118315\/revisions"}],"wp:attachment":[{"href":"https:\/\/youzum.net\/es\/wp-json\/wp\/v2\/media?parent=118315"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/youzum.net\/es\/wp-json\/wp\/v2\/categories?post=118315"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/youzum.net\/es\/wp-json\/wp\/v2\/tags?post=118315"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}